Robert F Keyes
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Explore the profile of Robert F Keyes including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
37
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Recent Articles
1.
Nunez R, Sidlowski P, Steen E, Wynia-Smith S, Sprague D, Keyes R, et al.
ACS Chem Biol
. 2024 Nov;
19(12):2418-2428.
PMID: 39556662
Histone lysine lactylation (Kla) regulates inflammatory gene expression in activated macrophages and mediates the polarization of inflammatory (M1) to reparative (M2) macrophages. However, the molecular mechanisms and key protein players...
2.
Pradhan B, Pavan M, Fisher C, Salmaso V, Wan T, Keyes R, et al.
J Med Chem
. 2024 Jul;
67(14):12221-12247.
PMID: 38959401
A adenosine receptor (AAR) positive allosteric modulators (PAMs) (2,4-disubstituted-1-imidazo[4,5-]quinolin-4-amines) allosterically increase the of AAR agonists, but not potency, due to concurrent orthosteric antagonism. Following mutagenesis/homology modeling of the proposed lipid-exposed...
3.
Fisher C, Pavan M, Salmaso V, Keyes R, Wan T, Pradhan B, et al.
Mol Pharmacol
. 2024 Jan;
105(3):213-223.
PMID: 38182432
This study describes the localization and computational prediction of a binding site for the A adenosine receptor (AAR) positive allosteric modulator 2-cyclohexyl-1-imidazo[4,5-c]quinolin-4-(3,4-dichlorophenyl)amine (LUF6000). The work reveals an extrahelical lipid-facing binding...
4.
Keyes R, McAllister D, Dwinell M, Smith B
STAR Protoc
. 2023 Aug;
4(3):102437.
PMID: 37552599
Triphenylphosphonium (TPP) compounds like mito-metformin (MMe) target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. Here, we present a protocol for synthesizing TPP analogs with selectivity for mammalian cancer...
5.
Yang M, Chiu J, Scartelli C, Ponzar N, Patel S, Patel A, et al.
J Thromb Haemost
. 2023 Apr;
21(8):2137-2150.
PMID: 37037379
Background: Oxidative stress contributes to thrombosis in atherosclerosis, inflammation, infection, aging, and malignancy. Oxidant-induced cysteine modifications, including sulfenylation, can act as a redox-sensitive switch that controls protein function. Protein disulfide...
6.
Ghosh A, Su Y, Forman M, Keyes R, Smith B, Hu X, et al.
J Virol
. 2023 Mar;
97(4):e0016023.
PMID: 36939350
Host-derived cellular pathways can provide an unfavorable environment for virus replication. These pathways have been a subject of interest for herpesviruses, including the betaherpesvirus human cytomegalovirus (HCMV). Here, we demonstrate...
7.
AbuEid M, Keyes R, McAllister D, Peterson F, Kadamberi I, Sprague D, et al.
iScience
. 2022 Dec;
25(12):105670.
PMID: 36567718
Triphenylphosphonium (TPP) conjugated compounds selectively target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. To date, studies have focused on modifying either the linker or the cargo of TPP-conjugated...
8.
Fisher C, Fallot L, Wan T, Keyes R, Suresh R, Rothwell A, et al.
ACS Pharmacol Transl Sci
. 2022 Aug;
5(8):625-641.
PMID: 35983277
The A adenosine receptor (AAR) is a promising therapeutic target for inflammatory diseases, cancer, and chronic neuropathic pain, with agonists already in advanced clinical trials. Here we report an in-depth...
9.
Guo X, Ghosh A, Keyes R, Peterson F, Forman M, Meyers D, et al.
Viruses
. 2022 Feb;
14(2).
PMID: 35215828
Treatment options for human cytomegalovirus (CMV) remain limited and are associated with significant adverse effects and the selection of resistant CMV strains in transplant recipients and congenitally infected infants. Although...
10.
Kapoor A, Ghosh A, Forman M, Hu X, Ye W, Southall N, et al.
J Med Chem
. 2020 Mar;
63(8):3896-3907.
PMID: 32191456
The critical consequences of human cytomegalovirus (HCMV) infection in the transplant population and in congenitally infected infants, the limited treatment options for HCMV, and the rise of resistant mutants toward...