Daniel J Sprague
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Explore the profile of Daniel J Sprague including associated specialties, affiliations and a list of published articles.
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19
Citations
77
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Recent Articles
11.
AbuEid M, Keyes R, McAllister D, Peterson F, Kadamberi I, Sprague D, et al.
iScience
. 2022 Dec;
25(12):105670.
PMID: 36567718
Triphenylphosphonium (TPP) conjugated compounds selectively target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. To date, studies have focused on modifying either the linker or the cargo of TPP-conjugated...
12.
Gunaratne G, Rebbeck R, McGurran L, Yan Y, Arzua T, Frolkis T, et al.
iScience
. 2022 Jan;
25(1):103706.
PMID: 35059610
Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in skeletal muscle, heart, and brain has been implicated in various...
13.
Sprague D, Getschman A, Fenske T, Volkman B, Smith B
ACS Med Chem Lett
. 2021 Nov;
12(11):1773-1782.
PMID: 34795867
CXCL12, a CXC-type chemokine, binds its receptor CXCR4, and the resulting signaling cascade is essential during development and subsequently in immune function. Pathologically, the CXCL12-CXCR4 signaling axis is involved in...
14.
Sprague D, Johnston J
Org Lett
. 2020 Oct;
22(21):8496-8499.
PMID: 33054232
The first enantio- and diastereoselective synthesis of Tepe's human proteasome modulator is described. Routes to this and other highly substituted chiral imidazolines generally produce racemic material. Key to the route...
15.
Goetz C, Sprague D, Smith B
Bioorg Chem
. 2020 Sep;
104:104232.
PMID: 32911193
Sirtuins are NAD-dependent protein deacylases that remove acyl modifications from acyl-lysine residues, resulting in essential cellular signaling. Recognized for their role in lifespan extension, humans encode seven sirtuin isoforms (Sirt1-7),...
16.
Olp M, Sprague D, Goetz C, Kathman S, Wynia-Smith S, Shishodia S, et al.
ACS Chem Biol
. 2020 Mar;
15(4):1036-1049.
PMID: 32149490
BRD4, a member of the bromodomain and extraterminal domain (BET) family, has emerged as a promising epigenetic target in cancer and inflammatory disorders. All reported BET family ligands bind within...
17.
Sprague D, Singh A, Johnston J
Chem Sci
. 2018 May;
9(8):2336-2339.
PMID: 29719706
The discovery that a -symmetric bis(AMidine) [BAM] catalyst promotes an -selective addition of α-substituted α-nitro esters to imines is described, providing α-substituted α,β-diamino ester products with high diastereo- and enantioselectivity....
18.
Arnold D, Penrod C, Sprague D, Hartert T
J Pediatr
. 2016 Jun;
175:236-236.e1.
PMID: 27255859
No abstract available.
19.
Sprague D, Nugent B, Yoder R, Vara B, Johnston J
Org Lett
. 2015 Feb;
17(4):880-3.
PMID: 25697748
Chiral diamine-derived hydrogen-bond donors were evaluated for their ability to effect stereocontrol in an intramolecular hetero-Diels-Alder (HDA) reaction hypothesized in the biosynthesis of brevianamides A and B. Collectively, these results...
20.
Narcis M, Sprague D, Captain B, Takenaka N
Org Biomol Chem
. 2012 Oct;
10(46):9134-6.
PMID: 23104427
The periselective Diels-Alder reaction of 5-substituted pentamethylcyclopentadienes and nitroethylene has been realized by helical-chiral hydrogen bond donor catalysts. To our knowledge, this represents the first asymmetric catalytic nitroalkene Diels-Alder reaction...