Daniel H Lackner
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Explore the profile of Daniel H Lackner including associated specialties, affiliations and a list of published articles.
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18
Citations
1331
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Recent Articles
1.
Lackner D, Carre A, Guzzardo P, Banning C, Mangena R, Henley T, et al.
Nat Commun
. 2015 Dec;
6:10237.
PMID: 26674669
Genome engineering has been greatly enhanced by the availability of Cas9 endonuclease that can be targeted to almost any genomic locus using so called guide RNAs (gRNAs). However, the introduction...
2.
Lackner D, Hayashi M, Cesare A, Karlseder J
Aging Cell
. 2014 May;
13(5):946-50.
PMID: 24863242
Replicative senescence is a fundamental tumor-suppressive mechanism triggered by telomere erosion that results in a permanent cell cycle arrest. To understand the impact of telomere shortening on gene expression, we...
3.
OSullivan R, Arnoult N, Lackner D, Oganesian L, Haggblom C, Corpet A, et al.
Nat Struct Mol Biol
. 2014 Jan;
21(2):167-74.
PMID: 24413054
The mechanism of activation of the alternative lengthening of telomeres (ALT) pathway of mammalian chromosome-end maintenance has been unclear. We have now discovered that co-depletion of the histone chaperones ASF1a...
4.
Lackner D, Karlseder J
Worm
. 2013 Sep;
2(1):e21073.
PMID: 24058854
In most eukaryotic organisms with a linear genome, the telomerase complex is essential for telomere maintenance and, thus, for genomic integrity. Proper telomerase function in stem and germ cell populations...
5.
Lackner D, Schmidt M, Wu S, Wolf D, Bahler J
Genome Biol
. 2012 Apr;
13(4):R25.
PMID: 22512868
Background: Gene expression is controlled globally and at multiple levels in response to environmental stress, but the relationships among these dynamic regulatory changes are not clear. Here we analyzed global...
6.
Lackner D, Raices M, Maruyama H, Haggblom C, Karlseder J
EMBO J
. 2012 Mar;
31(8):2024-33.
PMID: 22425786
To counteract replication-dependent telomere shortening most eukaryotic cells rely on the telomerase pathway, which is crucial for the maintenance of proliferative potential of germ and stem cell populations of multicellular...
7.
DAngelo M, Sebastian Gomez-Cavazos J, Mei A, Lackner D, Hetzer M
Dev Cell
. 2012 Jan;
22(2):446-58.
PMID: 22264802
Nuclear pore complexes (NPCs) are built from ∼30 different proteins called nucleoporins or Nups. Previous studies have shown that several Nups exhibit cell-type-specific expression and that mutations in NPC components...
8.
Lackner D, Durocher D, Karlseder J
PLoS One
. 2011 Jul;
6(6):e21407.
PMID: 21760879
Telomeres are nucleoprotein complexes which protect the ends of linear chromosomes from detection as DNA damage and provide a sequence buffer against replication-associated shortening. In mammals, telomeres consist of repetitive...
9.
St-Andre O, Lemieux C, Perreault A, Lackner D, Bahler J, Bachand F
J Biol Chem
. 2010 Jul;
285(36):27859-68.
PMID: 20622014
Meiosis is a cellular differentiation process in which hundreds of genes are temporally induced. Because the expression of meiotic genes during mitosis is detrimental to proliferation, meiotic genes must be...
10.
Lemay J, DAmours A, Lemieux C, Lackner D, St-Sauveur V, Bahler J, et al.
Mol Cell
. 2010 Feb;
37(1):34-45.
PMID: 20129053
Poly(A)-binding proteins (PABPs) are important to eukaryotic gene expression. In the nucleus, the PABP PABPN1 is thought to function in polyadenylation of pre-mRNAs. Deletion of fission yeast pab2, the homolog...