Samuel Marguerat
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Explore the profile of Samuel Marguerat including associated specialties, affiliations and a list of published articles.
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65
Citations
3460
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Recent Articles
1.
Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells
Anver S, Sumit A, Sun X, Hatimy A, Thalassinos K, Marguerat S, et al.
EMBO Rep
. 2024 Oct;
25(11):4921-4949.
PMID: 39358553
Genomes produce widespread long non-coding RNAs (lncRNAs) of largely unknown functions. We characterize aal1 (ageing-associated lncRNA), which is induced in quiescent fission yeast cells. Deletion of aal1 shortens the chronological...
2.
A coarse-grained resource allocation model of carbon and nitrogen metabolism in unicellular microbes
Kleijn I, Marguerat S, Shahrezaei V
J R Soc Interface
. 2023 Sep;
20(206):20230206.
PMID: 37751876
Coarse-grained resource allocation models (C-GRAMs) are simple mathematical models of cell physiology, where large components of the macromolecular composition are abstracted into single entities. The dynamics and steady-state behaviour of...
3.
Weith M, Grossbach J, Clement-Ziza M, Gillet L, Rodriguez-Lopez M, Marguerat S, et al.
Mol Syst Biol
. 2023 Jul;
19(8):e11493.
PMID: 37485750
The complexity of many cellular and organismal traits results from the integration of genetic and environmental factors via molecular networks. Network structure and effect propagation are best understood at the...
4.
Tang W, Solvsten Jorgensen A, Marguerat S, Thomas P, Shahrezaei V
Bioinformatics
. 2023 Jun;
39(7).
PMID: 37354494
Motivation: Gene expression is characterized by stochastic bursts of transcription that occur at brief and random periods of promoter activity. The kinetics of gene expression burstiness differs across the genome...
5.
Bertaux F, Kleijn I, Marguerat S, Shahrezaei V
MicroPubl Biol
. 2023 May;
2023.
PMID: 37193545
Steady-state cell size and geometry depend on growth conditions. Here, we use an experimental setup based on continuous culture and single-cell imaging to study how cell volume, length, width and...
6.
Garcia-Diaz C, Poysti A, Mereu E, Clements M, Brooks L, Galvez-Cancino F, et al.
Cell Rep
. 2023 May;
42(5):112472.
PMID: 37149862
Glioblastoma (GBM) recurrence originates from invasive margin cells that escape surgical debulking, but to what extent these cells resemble their bulk counterparts remains unclear. Here, we generated three immunocompetent somatic...
7.
Amodeo V, Davies T, Martinez-Segura A, Clements M, Simpson Ragdale H, Bailey A, et al.
Dev Cell
. 2023 Apr;
58(10):836-846.e6.
PMID: 37084728
Glioblastoma is thought to originate from neural stem cells (NSCs) of the subventricular zone that acquire genetic alterations. In the adult brain, NSCs are largely quiescent, suggesting that deregulation of...
8.
Solvsten Jorgensen A, Hill C, Sturrock M, Tang W, Karamched S, Gorup D, et al.
R Soc Open Sci
. 2023 Mar;
10(3):221444.
PMID: 36968241
Mathematical oncology provides unique and invaluable insights into tumour growth on both the microscopic and macroscopic levels. This review presents state-of-the-art modelling techniques and focuses on their role in understanding...
9.
Simpson Ragdale H, Clements M, Tang W, Deltcheva E, Andreassi C, Lai A, et al.
Curr Biol
. 2023 Feb;
33(6):1082-1098.e8.
PMID: 36841240
Despite their latent neurogenic potential, most normal parenchymal astrocytes fail to dedifferentiate to neural stem cells in response to injury. In contrast, aberrant lineage plasticity is a hallmark of gliomas,...
10.
Robles-Rebollo I, Cuartero S, Canellas-Socias A, Wells S, Karimi M, Mereu E, et al.
Nat Commun
. 2022 Jul;
13(1):4342.
PMID: 35896525
Innate immune responses rely on inducible gene expression programmes which, in contrast to steady-state transcription, are highly dependent on cohesin. Here we address transcriptional parameters underlying this cohesin-dependence by single-molecule...