Jan Karlseder
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Explore the profile of Jan Karlseder including associated specialties, affiliations and a list of published articles.
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57
Citations
5156
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Recent Articles
1.
Jones-Weinert C, Mainz L, Karlseder J
Nat Rev Mol Cell Biol
. 2024 Nov;
PMID: 39614014
Telomeres protect the ends of chromosomes but shorten following cell division in the absence of telomerase activity. When telomeres become critically short or damaged, a DNA damage response is activated....
2.
Schmidt T, Tyer C, Rughani P, Haggblom C, Jones J, Dai X, et al.
Nat Commun
. 2024 Jun;
15(1):5149.
PMID: 38890299
Telomeres are the protective nucleoprotein structures at the end of linear eukaryotic chromosomes. Telomeres' repetitive nature and length have traditionally challenged the precise assessment of the composition and length of...
3.
Nassour J, Przetocka S, Karlseder J
DNA Repair (Amst)
. 2023 Nov;
133:103591.
PMID: 37951043
Aging is marked by the gradual accumulation of deleterious changes that disrupt organ function, creating an altered physiological state that is permissive for the onset of prevalent human diseases. While...
4.
Moreno S, Fuste J, Kaiser M, Li J, Nassour J, Haggblom C, et al.
iScience
. 2023 Apr;
26(4):106405.
PMID: 37013192
The appropriate regulation of telomere length homeostasis is crucial for the maintenance of genome integrity. The telomere-binding protein TZAP has been suggested to regulate telomere length by promoting t-circle and...
5.
Jones C, Williams C, Moreno S, Morris D, Mondello C, Karlseder J, et al.
J Biol Chem
. 2023 Apr;
299(5):104665.
PMID: 37003504
Telomere length maintenance is crucial to cancer cell immortality. Up to 15% of cancers utilize a telomerase-independent, recombination-based mechanism termed alternative lengthening of telomeres (ALT). Currently, the primary ALT biomarker...
6.
Nassour J, Aguiar L, Correia A, Schmidt T, Mainz L, Przetocka S, et al.
Nature
. 2023 Feb;
614(7949):767-773.
PMID: 36755096
Cancers arise through the accumulation of genetic and epigenetic alterations that enable cells to evade telomere-based proliferative barriers and achieve immortality. One such barrier is replicative crisis-an autophagy-dependent program that...
7.
Jones C, Williams C, Moreno S, Morris D, Mondello C, Karlseder J, et al.
bioRxiv
. 2023 Feb;
PMID: 36747763
Telomere length maintenance is crucial to cancer cell immortality. Up to 15% of cancers utilize a telomerase-independent, recombination-based mechanism termed alternative lengthening of telomeres (ALT). The primary ALT biomarker is...
8.
Nassour J, Schmidt T, Karlseder J
Annu Rev Cancer Biol
. 2021 Sep;
5(1):59-77.
PMID: 34532611
Decades of study on cell cycle regulation have provided great insight into human cellular life span barriers, as well as their dysregulation during tumorigenesis. Telomeres, the extremities of linear chromosomes,...
9.
Spinler K, Bajaj J, Ito T, Zimdahl B, Hamilton M, Ahmadi A, et al.
Nat Commun
. 2020 Nov;
11(1):5998.
PMID: 33243988
Intratumoral heterogeneity is a common feature of many myeloid leukemias and a significant reason for treatment failure and relapse. Thus, identifying the cells responsible for residual disease and leukemia re-growth...
10.
Masamsetti V, Low R, Mak K, OConnor A, Riffkin C, Lamm N, et al.
Nat Commun
. 2019 Sep;
10(1):4224.
PMID: 31530811
Mitotic catastrophe is a broad descriptor encompassing unclear mechanisms of cell death. Here we investigate replication stress-driven mitotic catastrophe in human cells and identify that replication stress principally induces mitotic...