Daniel H Appella
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Explore the profile of Daniel H Appella including associated specialties, affiliations and a list of published articles.
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79
Citations
701
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Recent Articles
11.
Clausse V, Zheng H, Amarasekara H, Kruhlak M, Appella D
Nucleic Acids Res
. 2022 Oct;
50(19):10839-10856.
PMID: 36215040
Peptide nucleic acids (PNAs) are promising therapeutic molecules for gene modulation; however, they suffer from poor cell uptake. Delivery of PNAs into cells requires conjugation of the PNA to another...
12.
Robello M, Zheng H, Saha M, George Rosenker K, Debnath S, Kumar J, et al.
Eur J Med Chem
. 2022 Sep;
243:114763.
PMID: 36179402
The wild-type p53 induced phosphatase 1 (Wip1), a member of the serine/threonine-specific PP2C family, is overexpressed in numerous human cancers. Wip1 dephosphorylates p53 as well as several kinases (such as...
13.
Amarasekara H, Oshaben K, Jeans K, Rezvan Sangsari P, Morgan N, OFarrell B, et al.
Biopolymers
. 2021 Nov;
113(3):e23481.
PMID: 34812507
Routine patient testing for viral infections is critical to identify infected individuals for treatment and to prevent spreading of infections to others. Developing robust and reliable diagnostic tools to detect...
14.
Zheng H, Botos I, Clausse V, Nikolayevskiy H, Rastede E, Fouz M, et al.
Nucleic Acids Res
. 2021 Jan;
49(2):713-725.
PMID: 33406227
We report a series of synthetic, nucleic acid mimics with highly customizable thermodynamic binding to DNA. Incorporation of helix-promoting cyclopentanes into peptide nucleic acids (PNAs) increases the melting temperatures (Tm)...
15.
Tepper O, Zheng H, Appella D, Yavin E
Chem Commun (Camb)
. 2020 Dec;
57(4):540-543.
PMID: 33336664
Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine...
16.
Hait S, Hogge C, Rahman M, Ko E, Hunegnaw R, Mushtaq Z, et al.
J Immunol
. 2020 May;
204(12):3315-3328.
PMID: 32393514
Because of microbicide noncompliance and lack of a durable, highly effective vaccine, a combined approach might improve HIV prophylaxis. We tested whether a vaccine-microbicide combination would enhance protection against SIV...
17.
Fouz M, Appella D
Molecules
. 2020 Feb;
25(4).
PMID: 32059456
This review describes the application of peptide nucleic acids (PNAs) as clamps that prevent nucleic acid amplification of wild-type DNA so that DNA with mutations may be observed. These methods...
18.
Clausse V, Tao D, Debnath S, Fang Y, Tagad H, Wang Y, et al.
J Biol Chem
. 2019 Sep;
294(46):17654-17668.
PMID: 31481464
WT P53-Induced Phosphatase 1 (WIP1) is a member of the magnesium-dependent serine/threonine protein phosphatase (PPM) family and is induced by P53 in response to DNA damage. In several human cancers,...
19.
Zhu L, Rossi M, Cohen A, Pham J, Zheng H, Dattaroy D, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(37):18684-18690.
PMID: 31451647
Given the global epidemic in type 2 diabetes, novel antidiabetic drugs with increased efficacy and reduced side effects are urgently needed. Previous work has shown that M muscarinic acetylcholine (ACh)...
20.
Nikolayevskiy H, Robello M, Scerba M, Pasternak E, Saha M, Hartman T, et al.
Eur J Med Chem
. 2019 Jun;
178:818-837.
PMID: 31252286
Mercaptobenzamide thioesters and thioethers are chemically simple HIV-1 maturation inhibitors with a unique mechanism of action, low toxicity, and a high barrier to viral resistance. A structure-activity relationship (SAR) profile...