Ethan A Englund
Overview
Explore the profile of Ethan A Englund including associated specialties, affiliations and a list of published articles.
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12
Citations
171
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Recent Articles
1.
Shank N, George Rosenker K, Englund E, Dix A, Rastede E, Appella D
Methods Mol Biol
. 2019 Apr;
1973:131-145.
PMID: 31016699
Displaying ligands in a succinct and predictable manner is essential for elucidating multivalent molecular-level binding events. Organizing ligands with high precision and accuracy provides a distinct advantage over other ligand-display...
2.
Gaynutdinov T, Englund E, Appella D, Onyshchenko M, Neumann R, Panyutin I
Nucleic Acid Ther
. 2015 Feb;
25(2):78-84.
PMID: 25650982
Guanine (G)-rich DNA sequences can adopt four-stranded quadruplex conformations that may play a role in the regulation of genetic processes. To explore the possibility of targeted molecular recognition of DNA...
3.
Englund E, Gupta P, Micklitsch C, Onyshchenko M, Remeeva E, Neumann R, et al.
Chembiochem
. 2014 Jul;
15(13):1887-90.
PMID: 25044379
Recent studies have shown that guanine-rich (G-rich) sequences with the potential to form quadruplexes might play a role in normal transcription as well as overexpression of oncogenes. Chemical tools that...
4.
Englund E, Zhang N, Appella D
Methods Mol Biol
. 2013 Dec;
1050:13-8.
PMID: 24297347
Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to...
5.
Panyutin I, Onyshchenko M, Englund E, Appella D, Neumann R
Curr Pharm Des
. 2012 Mar;
18(14):1984-91.
PMID: 22376112
Regulation of genetic functions based on targeting DNA or RNA sequences with complementary oligonucleotides is especially attractive in the post-genome era. Oligonucleotides can be rationally designed to bind their targets...
6.
Englund E, Wang D, Fujigaki H, Sakai H, Micklitsch C, Ghirlando R, et al.
Nat Commun
. 2012 Jan;
3:614.
PMID: 22233624
Multivalent effects dictate the binding affinity of multiple ligands on one molecular entity to receptors. Integrins are receptors that mediate cell attachment through multivalent binding to peptide sequences within the...
7.
Onyshchenko M, Gaynutdinov T, Englund E, Appella D, Neumann R, Panyutin I
Nucleic Acids Res
. 2011 May;
39(16):7114-23.
PMID: 21593130
Guanine-rich sequences are highly abundant in the human genome, especially in regulatory regions. Because guanine-rich sequences have the unique ability to form G-quadruplexes, these structures may play a role in...
8.
Onyshchenko M, Gaynutdinov T, Englund E, Appella D, Neumann R, Panyutin I
Nucleic Acids Res
. 2009 Oct;
37(22):7570-80.
PMID: 19820116
Numerous regulatory genes have G-rich regions that can potentially form quadruplex structures, possibly playing a role in transcription regulation. We studied a G-rich sequence in the BCL2 gene 176-bp upstream...
9.
Englund E, Xu Q, Witschi M, Appella D
J Am Chem Soc
. 2006 Dec;
128(51):16456-7.
PMID: 17177367
Peptide nucleic acids (PNAs) are non-natural nucleic acid mimics that bind to complementary DNA and RNA with high affinity and selectivity. PNA can bind to nucleic acids in a number...
10.
Englund E, Appella D
Angew Chem Int Ed Engl
. 2006 Nov;
46(9):1414-8.
PMID: 17133633
No abstract available.