Daniel Conole
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Explore the profile of Daniel Conole including associated specialties, affiliations and a list of published articles.
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31
Citations
285
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Recent Articles
1.
Sharma R, Oyagawa C, Abbasi H, Dragunow M, Conole D
Trends Pharmacol Sci
. 2024 Oct;
45(11):997-1017.
PMID: 39438155
Central nervous system (CNS) drug development is plagued by high clinical failure rate. Phenotypic assays promote clinical translation of drugs by reducing complex brain diseases to measurable, clinically valid phenotypes....
2.
Draganov S, Gruet M, Conole D, Balcells C, Siskos A, Keun H, et al.
RSC Chem Biol
. 2024 Jul;
5(7):640-651.
PMID: 38966672
The post-translational modification (PTM) ADP-ribosylation plays an important role in cell signalling and regulating protein function and has been implicated in the development of multiple diseases, including breast and ovarian...
3.
Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30
Mondal M, Cao F, Conole D, Auner H, Tate E
RSC Chem Biol
. 2024 May;
5(5):439-446.
PMID: 38725909
Ubiquitin-specific protease 30 (USP30) is a deubiquitinating enzyme (DUB) localized at the mitochondrial outer membrane and involved in PINK1/Parkin-mediated mitophagy, pexophagy, BAX/BAK-dependent apoptosis, and IKKβ-USP30-ACLY-regulated lipogenesis/tumorigenesis. A USP30 inhibitor, MTX652,...
4.
Shah R, De Vita E, Sathyamurthi P, Conole D, Zhang X, Fellows E, et al.
J Med Chem
. 2024 Mar;
67(6):4641-4654.
PMID: 38478885
Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that have emerged as a therapeutic modality to induce targeted protein degradation (TPD) by harnessing cellular proteolytic degradation machinery. PROTACs which ligand the E3...
5.
Conole D, Cao F, Am Ende C, Xue L, Kantesaria S, Kang D, et al.
Angew Chem Int Ed Engl
. 2023 Oct;
62(47):e202311190.
PMID: 37779326
Deubiquitinases (DUBs) are a family of >100 proteases that hydrolyze isopeptide bonds linking ubiquitin to protein substrates, often leading to reduced substrate degradation through the ubiquitin proteasome system. Deregulation of...
6.
Zhang Q, Kounde C, Mondal M, Greenfield J, Baker J, Kotelnikov S, et al.
Chem Commun (Camb)
. 2022 Sep;
58(78):10933-10936.
PMID: 36065962
Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC...
7.
Jackson T, Vuorinen A, Josa-Cullere L, Madden K, Conole D, Cogswell T, et al.
iScience
. 2022 Aug;
25(8):104787.
PMID: 35992086
Despite much progress in developing better drugs, many patients with acute myeloid leukemia (AML) still die within a year of diagnosis. This is partly because it is difficult to identify...
8.
Chatzopoulou M, Conole D, Emer E, Rowley J, Willis N, Squire S, et al.
Bioorg Med Chem
. 2022 Jun;
69:116812.
PMID: 35772287
A therapeutic approach that holds the potential to treat all Duchenne muscular dystrophy (DMD) patient populations is utrophin modulation. Ezutromid, a first generation utrophin modulator which was later found to...
9.
Smith R, Perez-Ternero C, Conole D, Martin C, Myers S, Hobbs A, et al.
J Med Chem
. 2022 Mar;
65(7):5495-5513.
PMID: 35333039
C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis, which is at least partly mediated through agonism of natriuretic peptide receptor C (NPR-C), and loss of this...
10.
Sutherland H, Lu G, Tong A, Conole D, Franzblau S, Upton A, et al.
Eur J Med Chem
. 2021 Dec;
229:114059.
PMID: 34963068
Drug resistant tuberculsosis (TB) is global health crisis that demands novel treatment strategies. Bacterial ATP synthase inhibitors such as bedaquiline and next-generation analogues (such as TBAJ-876) have shown promising efficacy...