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Scott G Franzblau

Explore the profile of Scott G Franzblau including associated specialties, affiliations and a list of published articles. Areas
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Articles 243
Citations 3466
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Recent Articles
1.
Kumar B, Talamadla M, Kumar T, Nandikolla A, Khetmalis Y, Shetye G, et al.
Bioorg Med Chem Lett . 2025 Mar; 121:130177. PMID: 40058415
In this work, novel 2-substituted-3-((1-substituted-1H-1,2,3-triazol-4-yl) methoxy) quinoxaline analogues were designed, synthesized, and various analytical techniques, viz., H NMR, C NMR, and Mass spectrometry, were deployed in the structure confirmation of...
2.
Georgiades J, Berkovich D, McKee S, Smith A, Sankaran B, Flentie K, et al.
ACS Infect Dis . 2025 Feb; 11(3):689-702. PMID: 39950956
Antibiotics that operate multiple mechanisms of action are a promising strategy to combat growing resistance. Previous studies have shown that dual action antifolates formed from a pyrroloquinazolinediamine core can inhibit...
3.
Tan J, Augustinovic M, Omar A, Lourenzon V, Krull N, Lopez X, et al.
ACS Omega . 2024 Nov; 9(44):44749-44759. PMID: 39524626
We established a university-community partnership with the Boys and Girls Clubs of Chicago (BGCC)-named b-to involve middle school students in antibiotic discovery research. In the course of working with a...
4.
Nandikolla A, Khetmalis Y, Kumar B, Chandu A, Karan Kumar B, Shetye G, et al.
RSC Med Chem . 2023 Aug; 14(8):1549-1561. PMID: 37593576
The phenanthridine core exhibits antitubercular activity, according to reports from the literature. Several 1,2,3-triazole-based heterocyclic compounds are well-known antitubercular agents. A series of twenty-five phenanthridine amide and 1,2,3-triazole derivatives are...
5.
Lee J, Ma R, Nguyen L, Khan S, Qader M, Mpofu E, et al.
ACS Infect Dis . 2023 Jul; 9(8):1593-1601. PMID: 37450563
For over a century, researchers have cultured microorganisms together on solid support─typically agar─in order to observe growth inhibition via antibiotic production. These simple bioassays have been critical to both academic...
6.
Khatri Chhetri B, Bhanushali R, Liang Y, Cepeda M, Niradininoco A, Soapi K, et al.
J Nat Prod . 2023 Mar; 86(3):574-581. PMID: 36881908
Tuberculosis (TB) is a dreadful infectious disease and a leading cause of mortality and morbidity worldwide, second in 2020 only to severe acute respiratory syndrome 2 (SARS-Cov-2). With limited therapeutic...
7.
Zhang J, Lair C, Roubert C, Amaning K, Barrio M, Benedetti Y, et al.
Cell . 2023 Feb; 186(5):1013-1025.e24. PMID: 36827973
The emergence of drug-resistant tuberculosis has created an urgent need for new anti-tubercular agents. Here, we report the discovery of a series of macrolides called sequanamycins with outstanding in vitro...
8.
Lee S, Shetye G, Son S, Lee H, Klein L, Yoshihara J, et al.
Plants (Basel) . 2023 Jan; 12(1). PMID: 36616162
The fruits of Amomun tsao-ko (Chinese black cardamom; Zingiberaceae) contain an abundance of essential oils, which have previously demonstrated significant antimicrobial activity. In our preliminary search for natural anti-tuberculosis agents,...
9.
Kamat V, Poojary B, Puthran D, Das V, Kumar B, Sankaranarayan M, et al.
Arch Pharm (Weinheim) . 2022 Dec; 356(3):e2200444. PMID: 36461683
In the present investigation, we devolved and synthesized a new series of pyrazole-embedded thiazolidin-4-one derivatives (9a-p) with the goal to produce promising antitubercular leads. The in vitro antimycobacterial activity of...
10.
Zhou B, Shetye G, Wolf N, Chen S, Qader M, Ray G, et al.
Org Lett . 2022 Oct; 24(40):7265-7270. PMID: 36194676
Four new rufomycins, compounds -, named rufomycins 56, 57, 58, and 61, respectively, exhibiting new skeletal features, were obtained from strain MJM3502 and were fully characterized. Compounds and possess a...