D L Eaton
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Explore the profile of D L Eaton including associated specialties, affiliations and a list of published articles.
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130
Citations
2305
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Recent Articles
11.
Cheesman M, Kneller M, Kelly E, Thompson S, Yeung C, Eaton D, et al.
Protein Expr Purif
. 2001 Feb;
21(1):81-6.
PMID: 11162390
Cyclohexanone monooxygenase (CMO) is a soluble flavoenzyme originally isolated from Acinetobacter spp. which carries out Baeyer-Villiger reactions with cyclic ketone substrates. In the present study we cloned the Acinetobacter CMO...
12.
Wagemaker G, Neelis K, Hartong SCC , Wognum A, Thomas G, Fielder P, et al.
Stem Cells
. 2000 Sep;
16 Suppl 2:127-41.
PMID: 11012185
Radiation-induced pancytopenia proved to be a suitable model system in mice and rhesus monkeys to study thrombopoietin (TPO) target cell range and efficacy. TPO was highly effective in rhesus monkeys...
13.
Chen Q, Solar G, Eaton D, de Sauvage F
Stem Cells
. 2000 Sep;
16 Suppl 2:31-6.
PMID: 11012175
Thrombopoietin is a lineage-dominant cytokine involved primarily in the control of platelet production. The physiological importance of thrombopoietin (TPO) in the regulation of megakaryocyte and platelet production was demonstrated by...
14.
15.
Thompson S, White C, Krejsa C, Eaton D, Kavanagh T
Toxicol Sci
. 2000 Aug;
57(1):141-6.
PMID: 10966520
The antioxidant tripeptide glutathione has been proposed to be important in defense against oxidative stress and heavy metal toxicity. We evaluated alterations in glutathione regulation and synthesis associated with low-level...
16.
Wang C, Bammler T, Guo Y, Kelly E, Eaton D
Toxicol Sci
. 2000 Jun;
56(1):26-36.
PMID: 10869451
Mice are resistant to the carcinogenic effects of the mycotoxin aflatoxin B(1) (AFB(1)) because they constitutively express an alpha-class glutathione S-transferase (mGSTA3-3) that has high (approximately 200,000 pmol/min/mg) activity toward...
17.
Sweeney C, Farrow D, Schwartz S, Eaton D, Checkoway H, Vaughan T
Cancer Epidemiol Biomarkers Prev
. 2000 May;
9(4):449-54.
PMID: 10794492
Renal cell carcinoma (RCC) has known environmental risk factors, notably smoking, and enzymes that biotransform carcinogens have high levels of activity in the kidney. However, a possible role of polymorphisms...
18.
Eaton D
Neurotoxicology
. 2000 May;
21(1-2):101-11.
PMID: 10794390
Numerous specific genetic polymorphisms (PM) in the multi-gene families of cytochromes P450 (CYPs) and glutathione S-transferases (GSTs) have been described in the human population in the past decade. For example,...
19.
Bammler T, Slone D, Eaton D
Toxicol Sci
. 2000 Apr;
54(1):30-41.
PMID: 10746929
Following aflatoxin B1 (AFB) exposure, rats readily develop liver tumors. However, treatment of rats with a variety of compounds, including the synthetic dithiolthione oltipraz and the antioxidant ethoxyquin, protects these...
20.
Vasiliou V, Buetler T, Eaton D, Nebert D
Biochem Pharmacol
. 2000 Feb;
59(6):703-12.
PMID: 10677587
Induction of approximately one dozen genes and/or enzyme activities in liver of the untreated newborn c(14CoS)/c(14CoS) mouse-when compared with the c(ch)/c(14CoS) heterozygote or the c(ch)/c(ch) wild-type-is the result of enhanced...