C D Klaassen
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Explore the profile of C D Klaassen including associated specialties, affiliations and a list of published articles.
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391
Citations
4169
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Recent Articles
1.
Cazanave S, Wang X, Zhou H, Rahmani M, Grant S, Durrant D, et al.
Cell Death Differ
. 2014 Apr;
21(8):1303-12.
PMID: 24769730
Non-alcoholic steatohepatitis is characterized by hepatic steatosis, elevated levels of circulating free fatty acids (FFA) and hepatocyte lipoapoptosis. This lipoapoptosis requires increased JNK phosphorylation and activation of the pro-apoptotic BH3-only...
2.
Martin L, Wilson D, Reuhl K, Gallo M, Klaassen C
Drug Metab Dispos
. 2011 Dec;
40(3):588-95.
PMID: 22187485
Polychlorinated biphenyl (PCB) congeners differentially reduce serum thyroxine (T(4)) in rats, but little is known about their ability to affect biliary excretion of T(4). Thus, male Sprague-Dawley rats were orally...
3.
Aleksunes L, Yeager R, Klaassen C
Xenobiotica
. 2009 Jun;
39(7):514-22.
PMID: 19480556
Multidrug resistance-associated proteins 2-4 (MRP2-4) are membrane efflux transporters critical for the hepatic clearance of pharmaceuticals and endogenous chemicals. Little is known about the constitutive regulation of MRP2-4 mRNA in...
4.
Shelby M, Klaassen C
Drug Metab Dispos
. 2006 Jul;
34(10):1772-8.
PMID: 16855052
Microsomal enzyme inducers (MEIs) up-regulate phase I biotransformation enzymes, most notably cytochromes P450. Transcriptional up-regulation by MEIs occurs through at least three nuclear receptor mechanisms: constitutive androstane receptor (CAR; CYP2B...
5.
Maher J, Slitt A, Callaghan T, Cheng X, Cheung C, Gonzalez F, et al.
Biochem Pharmacol
. 2006 Jun;
72(4):512-22.
PMID: 16806085
The transcription factor hepatocyte nuclear factor 1alpha (HNF1alpha) is involved in regulation of glucose metabolism and transport, and in the expression of several drug and bile acid metabolizing enzymes. Targeted...
6.
Slitt A, Cherrington N, Fisher C, Negishi M, Klaassen C
Drug Metab Dispos
. 2006 Apr;
34(7):1190-7.
PMID: 16621935
trans-Stilbene oxide (TSO) is a synthetic proestrogen that induces phase I and II drug-metabolizing enzymes in rat liver. The purpose of this study was to determine whether TSO also induces...
7.
Maher J, Cheng X, Tanaka Y, Scheffer G, Klaassen C
Biochem Pharmacol
. 2006 Mar;
71(10):1470-8.
PMID: 16529719
Multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) are expressed at much higher levels in female than male kidney. Sex steroids and sex-specific growth hormone (GH) secretion patterns often...
8.
Slitt A, Cherrington N, Dieter M, Aleksunes L, Scheffer G, Huang W, et al.
Mol Pharmacol
. 2006 Feb;
69(5):1554-63.
PMID: 16449384
trans-Stilbene oxide (TSO) induces drug metabolizing enzymes in rat and mouse liver. TSO is considered a phenobarbital-like compound because it induces Cyp2B mRNA expression in liver. Phenobarbital increases Cyp2B expression...
9.
Maher J, Cherrington N, Slitt A, Klaassen C
Life Sci
. 2005 Nov;
78(19):2219-25.
PMID: 16260000
Multidrug resistance-associated proteins (Mrps) are ATP-dependent transporters which transport a wide variety of anionic and cationic compounds. The purpose of this study was to determine the tissue distribution of Mrp5...
10.
Klaassen C, Slitt A
Curr Drug Metab
. 2005 Aug;
6(4):309-28.
PMID: 16101571
Chemicals that increase expression of phase-I and -II biotransformation enzymes in liver, as well as enhance hepatic uptake and biliary excretion are often referred to as microsomal enzyme inducers (MEIs)....