P L Stapleton
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Explore the profile of P L Stapleton including associated specialties, affiliations and a list of published articles.
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9
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140
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Recent Articles
1.
Gross-Steinmeyer K, Stapleton P, Tracy J, Bammler T, Lehman T, Strom S, et al.
Xenobiotica
. 2005 Jul;
35(5):419-38.
PMID: 16012075
1. Previous studies reported that rat hepatocytes overlaid with extracellular matrix components (Matrigel) maintain the expression and responsiveness of drug-metabolizing enzymes. However, whether Matrigel provides similar advantages in human hepatocytes...
2.
Gross-Steinmeyer K, Stapleton P, Liu F, Tracy J, Bammler T, Quigley S, et al.
Xenobiotica
. 2005 Jan;
34(7):619-32.
PMID: 15672752
1. The naturally occurring compounds curcumin (CUR), 3,3'-diindolylmethane (DIM), isoxanthohumol (IXN), 8-prenylnaringenin (8PN), phenethyl isothiocyanate (PEITC) and sulforaphane (SFN) protect animals against chemically induced tumours. Putative chemoprotective mechanisms include modulated...
3.
Gallagher E, Kunze K, Stapleton P, Eaton D
Toxicol Appl Pharmacol
. 1996 Dec;
141(2):595-606.
PMID: 8975785
The combined presence of CYP1A2 and 3A4, both of which oxidize aflatoxin B1 (AFB1) to the reactive aflatoxin B1-8,9-epoxide (AFBO) and to hydroxylated inactivation products aflatoxin M1 (AFM1) and aflatoxin...
4.
Gallagher E, Buetler T, Stapleton P, Wang C, Stahl D, Eaton D
Toxicol Appl Pharmacol
. 1995 Sep;
134(1):81-91.
PMID: 7676460
Although the mechanisms responsible for chemically induced oxidative stress are under intense investigation, little is known about the effects of prooxidant chemicals on the expression of drug-metabolizing enzymes. We examined...
5.
Slone D, Gallagher E, Ramsdell H, Rettie A, Stapleton P, Berlad L, et al.
Pharmacogenetics
. 1995 Aug;
5(4):224-33.
PMID: 8528269
Hepatic cytosolic fractions prepared from 14 human donors were analysed for glutathione S-transferase (GST) activity towards synthetic aflatoxin B1-8,9-epoxide (AFBO). In addition, GST-AFBO activity of pooled human liver cytosols was...
6.
Gallagher E, Wienkers L, Stapleton P, Kunze K, Eaton D
Cancer Res
. 1994 Jan;
54(1):101-8.
PMID: 8261428
The metabolism of the carcinogenic mycotoxin aflatoxin B1 (AFB1) was examined in microsomes derived from human lymphoblastoid cell lines expressing transfected CYP1A2 or CYP3A4 complementary DNAs and in microsomes prepared...
7.
Zales V, Stapleton P
Pediatr Clin North Am
. 1993 Oct;
40(5):1023-46.
PMID: 8414708
Since the advent of cyclosporine A, cardiac transplantation has been offered routinely for adolescents and children with cardiomyopathy refractory to medical management. Recently, cardiac transplantation has been offered to neonates...
8.
Eaton D, Stapleton P
Anal Biochem
. 1989 Apr;
178(1):153-8.
PMID: 2729567
Cytosolic glutathione S-transferase (GST) and microsomal epoxide hydrolase (EH) are important detoxification enzymes for many epoxide xenobiotics. We have developed a rapid, simple, and convenient HPLC assay which measures both...
9.
Voudrias E, Larson R, Snoeyink V, Chen A, Stapleton P
Environ Health Perspect
. 1986 Nov;
69:97-100.
PMID: 3028770
Granular activated carbon (GAC), in the presence of dilute aqueous hypochlorite solutions typical of those used in water treatment, was converted to a reagent capable of carrying out free-radical coupling...