Sean E Egan
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Explore the profile of Sean E Egan including associated specialties, affiliations and a list of published articles.
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57
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2308
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Recent Articles
1.
Chung W, Wang W, Challagundla L, Moore C, Egan S, Xu K
Oncogenesis
. 2025 Jan;
14(1):2.
PMID: 39890784
Notch signaling is altered in breast cancer. Recent studies highlighted both tumor-suppressive and oncogenic roles for Notch in this tissue. The function of Jagged1, the most highly expressed Notch ligand...
2.
Yang Y, Fekete A, Arsenault J, Sengar A, Aitoubah J, Grande G, et al.
J Physiol
. 2024 Oct;
PMID: 39383250
Intersectin-1 (Itsn1) is a scaffold protein that plays a key role in coupling exocytosis and endocytosis of synaptic vesicles (SVs). However, it is unclear whether and how Itsn1 regulates these...
3.
Raghuram N, Temel E, Kawamata T, Kozma K, Loch A, Wang W, et al.
Breast Cancer Res
. 2024 May;
26(1):86.
PMID: 38807216
Copy number gains in genes coding for Rho activating exchange factors as well as losses affecting genes coding for RhoGAP proteins are common in breast cancer (BC), suggesting that elevated...
4.
Jiang Z, Ju Y, Ali A, Chung P, Skowron P, Wang D, et al.
Nat Commun
. 2023 Jul;
14(1):4313.
PMID: 37463901
Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary cancer is still contentious. To elucidate this relationship...
5.
Chung W, Egan S, Xu K
Development
. 2022 Oct;
149(19).
PMID: 36205077
Notch3 promotes mammary luminal cell specification and forced Notch3 activation can induce mammary tumor formation. However, recent studies suggest a tumor-suppressive role for Notch3. Here, we report on Notch3 expression...
6.
Langille E, Al-Zahrani K, Ma Z, Liang M, Uuskula-Reimand L, Espin R, et al.
Cancer Discov
. 2022 Sep;
12(12):2930-2953.
PMID: 36108220
Significance: Infrequently mutated genes comprise most of the mutational burden in breast tumors but are poorly understood. In vivo CRISPR screening identified functional tumor suppressors that converged on epigenetic regulation....
7.
Schachter N, Adams J, Skowron P, Kozma K, Lee C, Raghuram N, et al.
Nat Commun
. 2021 Sep;
12(1):5238.
PMID: 34475389
The most common events in breast cancer (BC) involve chromosome arm losses and gains. Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from transposon-based screens in 8...
8.
Roth D, Baddam P, Lin H, Vidal-Garcia M, Aponte J, De Souza S, et al.
Front Cell Dev Biol
. 2021 May;
9:645386.
PMID: 33996804
Epigenetic and chromatin regulation of craniofacial development remains poorly understood. Ankyrin Repeat Domain 11 () is a chromatin regulator that has previously been shown to control neural stem cell fates...
9.
Kozma K, Done S, Egan S
EMBO Mol Med
. 2021 Feb;
13(3):e13807.
PMID: 33616312
Invasive lobular carcinoma (ILC) of the breast is a very common disease. Despite its prevalence, these tumors are relatively understudied. One reason for this is a relative lack of models...
10.
Zacksenhaus E, Egan S
Cancers (Basel)
. 2021 Feb;
13(4).
PMID: 33578666
Metastatic dissemination of cancer cells, their colonization at distal sites, and ultimate disruption of tissue physiology are the root causes of most deaths from solid cancers, particularly in tumor types...