Bethany L Macleod
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Explore the profile of Bethany L Macleod including associated specialties, affiliations and a list of published articles.
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10
Citations
681
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Recent Articles
1.
Snell L, Xu W, Abd-Rabbo D, Boukhaled G, Guo M, Macleod B, et al.
Nat Immunol
. 2021 Nov;
22(12):1524-1537.
PMID: 34795443
Inhibiting PD-1:PD-L1 signaling has transformed therapeutic immune restoration. CD4 T cells sustain immunity in chronic infections and cancer, yet little is known about how PD-1 signaling modulates CD4 helper T...
2.
Xu W, Snell L, Guo M, Boukhaled G, Macleod B, Li M, et al.
Immunity
. 2021 Jan;
54(3):526-541.e7.
PMID: 33515487
Chronic viral infections increase severity of Mycobacterium tuberculosis (Mtb) coinfection. Here, we examined how chronic viral infections alter the pulmonary microenvironment to foster coinfection and worsen disease severity. We developed...
3.
Macleod B, Elsaesser H, Snell L, Dickson R, Guo M, Hezaveh K, et al.
J Exp Med
. 2020 Sep;
217(12).
PMID: 32880629
Many pathogens subvert intestinal immunity to persist within the gastrointestinal tract (GIT); yet, the underlying mechanisms that enable sanctuary specifically in this reservoir are unclear. Using mass cytometry and network...
4.
Halaby M, Hezaveh K, Lamorte S, Ciudad M, Kloetgen A, Macleod B, et al.
Sci Immunol
. 2019 Dec;
4(42).
PMID: 31836669
General control nonderepressible 2 (GCN2) is an environmental sensor controlling transcription and translation in response to nutrient availability. Although GCN2 is a putative therapeutic target for immuno-oncology, its role in...
5.
Gadalla R, Noamani B, Macleod B, Dickson R, Guo M, Xu W, et al.
Front Oncol
. 2019 Jun;
9:415.
PMID: 31165047
Flow cytometry is a widely applied approach for exploratory immune profiling and biomarker discovery in cancer and other diseases. However, flow cytometry is limited by the number of parameters that...
6.
Snell L, Macleod B, Law J, Osokine I, Elsaesser H, Hezaveh K, et al.
Immunity
. 2018 Oct;
49(4):678-694.e5.
PMID: 30314757
CD8 T cell exhaustion impedes control of chronic viral infection; yet how new T cell responses are mounted during chronic infection is unclear. Unlike T cells primed at the onset...
7.
Collins N, Jiang X, Zaid A, Macleod B, Li J, Park C, et al.
Nat Commun
. 2016 May;
7:11514.
PMID: 27160938
Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that...
8.
Stankovic S, Harpur C, Macleod B, Whitney P, Gebhardt T, Brooks A
J Immunol
. 2015 Oct;
195(10):4892-9.
PMID: 26453747
The ability of CD4 T cells to give rise to specialized T follicular helper cells (TFH) critical to initiating appropriate Ab responses is regulated by environmental cues in lymphoid tissues...
9.
Mackay L, Braun A, Macleod B, Collins N, Tebartz C, Bedoui S, et al.
J Immunol
. 2015 Jan;
194(5):2059-63.
PMID: 25624457
Tissue-resident memory T cells provide local immune protection in barrier tissues, such as skin and mucosa. However, the molecular mechanisms controlling effector T cell retention and subsequent memory formation in...
10.
Macleod B, Bedoui S, Hor J, Mueller S, Russell T, Hollett N, et al.
PLoS Pathog
. 2014 Aug;
10(8):e1004303.
PMID: 25121482
Efficient infection control requires potent T-cell responses at sites of pathogen replication. However, the regulation of T-cell effector function in situ remains poorly understood. Here, we show key differences in...