Cory D Emal
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Explore the profile of Cory D Emal including associated specialties, affiliations and a list of published articles.
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10
Citations
144
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Recent Articles
1.
Compartmentalized Actions of the Plasminogen Activator Inhibitors, PAI-1 and Nsp, in Ischemic Stroke
Torrente D, Su E, Fredriksson L, Warnock M, Bushart D, Mann K, et al.
Transl Stroke Res
. 2022 Feb;
13(5):801-815.
PMID: 35122213
Tissue plasminogen activator (tPA) is a multifunctional protease. In blood tPA is best understood for its role in fibrinolysis, whereas in the brain tPA is reported to regulate blood-brain barrier...
2.
Jilkova A, Rubesova P, Fanfrlik J, Fajtova P, rezacova P, Brynda J, et al.
ACS Infect Dis
. 2020 Nov;
7(5):1077-1088.
PMID: 33175511
Schistosomiasis, a parasitic disease caused by blood flukes of the genus , is a global health problem with over 200 million people infected. Treatment relies on just one drug, and...
3.
Khoukaz H, Ji Y, Braet D, Vadali M, Abdelhamid A, Emal C, et al.
Arterioscler Thromb Vasc Biol
. 2020 Apr;
40(6):1479-1490.
PMID: 32268785
Objective: Enhanced expression of PAI-1 (plasminogen activator inhibitor-1) has been implicated in atherosclerosis formation in humans with obesity and metabolic syndrome. However, little is known about the effects of pharmacological...
4.
Migliorini M, Li S, Zhou A, Emal C, Lawrence D, Strickland D
J Biol Chem
. 2019 Dec;
295(1):212-222.
PMID: 31792055
It is well-established that complexes of plasminogen-activator inhibitor 1 (PAI-1) with its target enzymes bind tightly to low-density lipoprotein (LDL) receptor-related protein 1 (LRP1), but the molecular details of this...
5.
Reinke A, Li S, Warnock M, Shaydakov M, Guntaka N, Su E, et al.
J Biol Chem
. 2018 Dec;
294(5):1464-1477.
PMID: 30510136
Plasminogen activator inhibitor type-1 (PAI-1) is a ine rotease hibitor (serpin) implicated in numerous pathological processes, including coronary heart disease, arterial and venous thrombosis, and chronic fibrotic diseases. These associations...
6.
Li S, Reinke A, Sanders K, Emal C, Whisstock J, Stuckey J, et al.
Proc Natl Acad Sci U S A
. 2013 Dec;
110(51):E4941-9.
PMID: 24297881
Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) family. Excessive PAI-1 activity is associated with human disease, making it an attractive pharmaceutical target. However,...
7.
Cale J, Li S, Warnock M, Su E, North P, Sanders K, et al.
J Biol Chem
. 2010 Jan;
285(11):7892-902.
PMID: 20061381
Plasminogen activator inhibitor type 1, (PAI-1) the primary inhibitor of the tissue-type (tPA) and urokinase-type (uPA) plasminogen activators, has been implicated in a wide range of pathological processes, making it...
8.
El-Ayache N, Li S, Warnock M, Lawrence D, Emal C
Bioorg Med Chem Lett
. 2010 Jan;
20(3):966-70.
PMID: 20056540
Inactivators of plasminogen activator inhibitor-1 (PAI-1) have been identified as possible treatments for a range of conditions, including atherosclerosis, venous thrombosis, and obesity. We describe the synthesis and inhibitory activity...
9.
Boitano A, Emal C, Leonetti F, Blatt N, Dineen T, Ellman J, et al.
Bioorg Med Chem Lett
. 2003 Sep;
13(19):3327-30.
PMID: 12951119
Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have been designed, synthesized, and evaluated in cell-culture assays. The results...
10.
Shenai B, Lee B, Alvarez-Hernandez A, Chong P, Emal C, Neitz R, et al.
Antimicrob Agents Chemother
. 2002 Dec;
47(1):154-60.
PMID: 12499184
The Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3 appear to be required for hemoglobin hydrolysis by intraerythrocytic malaria parasites. Previous studies showed that peptidyl vinyl sulfone inhibitors of falcipain-2 blocked...