Mark Warnock
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Explore the profile of Mark Warnock including associated specialties, affiliations and a list of published articles.
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22
Citations
679
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Recent Articles
1.
Torrente D, Su E, Citalan-Madrid A, Schielke G, Magaoay D, Warnock M, et al.
J Neuroinflammation
. 2025 Jan;
22(1):8.
PMID: 39810216
The thrombolytic protease tissue plasminogen activator (tPA) is expressed in the CNS, where it regulates diverse functions including neuronal plasticity, neuroinflammation, and blood-brain-barrier integrity. However, its role in different brain...
2.
Sisson T, Osterholzer J, Leung L, Basrur V, Nesvizhskii A, Subbotina N, et al.
bioRxiv
. 2024 Aug;
PMID: 39211273
Plasminogen activator inhibitor-1 (PAI-1) has been previously shown to promote lung fibrosis via a mechanism that requires an intact vitronectin (VTN) binding site. In the present study, employing two distinct...
3.
Pontius M, Ku C, Osmond M, Disharoon D, Liu Y, Warnock M, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(10):e2315083121.
PMID: 38408253
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for ischemic stroke but carries significant risks, including major hemorrhage. Additional options are needed, especially in small vessel thrombi which account...
4.
Torrente D, Su E, Schielke G, Warnock M, Mann K, Lawrence D
J Neuroinflammation
. 2023 Mar;
20(1):56.
PMID: 36864439
Background: Noradrenergic neurons in the locus coeruleus (LC) are the primary source of norepinephrine (NE) in the brain and degeneration of these neurons is reported in the early stages of...
5.
Compartmentalized Actions of the Plasminogen Activator Inhibitors, PAI-1 and Nsp, in Ischemic Stroke
Torrente D, Su E, Fredriksson L, Warnock M, Bushart D, Mann K, et al.
Transl Stroke Res
. 2022 Feb;
13(5):801-815.
PMID: 35122213
Tissue plasminogen activator (tPA) is a multifunctional protease. In blood tPA is best understood for its role in fibrinolysis, whereas in the brain tPA is reported to regulate blood-brain barrier...
6.
Zuo Y, Warnock M, Harbaugh A, Yalavarthi S, Gockman K, Zuo M, et al.
Sci Rep
. 2021 Jan;
11(1):1580.
PMID: 33452298
Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients. Understanding the balance between coagulation...
7.
Zuo Y, Warnock M, Harbaugh A, Yalavarthi S, Gockman K, Zuo M, et al.
medRxiv
. 2020 Sep;
PMID: 32909005
Patients with coronavirus disease-19 ( ) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients. Understanding the balance between...
8.
Waack U, Warnock M, Yee A, Huttinger Z, Smith S, Kumar A, et al.
mBio
. 2018 Dec;
9(6).
PMID: 30563903
Antibiotic-resistant is increasingly recognized as a cause of difficult-to-treat nosocomial infections, including pneumonia, wound infections, and bacteremia. Previous studies have demonstrated that the metalloprotease CpaA contributes to virulence and prolongs...
9.
Reinke A, Li S, Warnock M, Shaydakov M, Guntaka N, Su E, et al.
J Biol Chem
. 2018 Dec;
294(5):1464-1477.
PMID: 30510136
Plasminogen activator inhibitor type-1 (PAI-1) is a ine rotease hibitor (serpin) implicated in numerous pathological processes, including coronary heart disease, arterial and venous thrombosis, and chronic fibrotic diseases. These associations...
10.
Su E, Fredriksson L, Kanzawa M, Moore S, Folestad E, Stevenson T, et al.
Front Cell Neurosci
. 2015 Oct;
9:385.
PMID: 26500491
Current therapies for Traumatic brain injury (TBI) focus on stabilizing individuals and on preventing further damage from the secondary consequences of TBI. A major complication of TBI is cerebral edema,...