Corey L Strickland
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Explore the profile of Corey L Strickland including associated specialties, affiliations and a list of published articles.
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9
Citations
62
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Recent Articles
1.
Hovlid M, Edelstein R, Henry O, Ochocki J, DeGraw A, Lenevich S, et al.
Chem Biol Drug Des
. 2009 Dec;
75(1):51-67.
PMID: 19954434
Photoactive analogs of farnesyl diphosphate (FPP) are useful probes in studies of enzymes that employ this molecule as a substrate. Here, we describe the preparation and properties of two new...
2.
DeGraw A, Zhao Z, Strickland C, Taban A, Hsieh J, Jefferies M, et al.
J Org Chem
. 2007 May;
72(13):4587-95.
PMID: 17477573
A number of biochemical processes rely on isoprenoids, including the post-translational modification of signaling proteins and the biosynthesis of a wide array of compounds. Photoactivatable analogues have been developed to...
3.
Ingram R, Orth P, Strickland C, Le H, Madison V, Beyer B
Protein Eng Des Sel
. 2006 Feb;
19(4):155-61.
PMID: 16459338
The crystallization of TNF-alpha converting enzyme (TACE) has been useful in understanding the structure-activity relationships of new chemical entities. However, the propensity of TACE to undergo autoproteolysis has made enzyme...
4.
Ohkanda J, Strickland C, Blaskovich M, Carrico D, Lockman J, Vogt A, et al.
Org Biomol Chem
. 2006 Feb;
4(3):482-92.
PMID: 16446806
A series of imidazole-containing peptidomimetic PFTase inhibitors and their co-crystal structures bound to PFTase and FPP are reported. The structures reveal that the peptidomimetics adopt a similar conformation to that...
5.
Huang C, Stauffer T, Strickland C, Reader J, Huang H, Li G, et al.
Bioorg Med Chem Lett
. 2005 Nov;
16(3):507-11.
PMID: 16289818
Farnesyltransferase inhibitors identified from an ECLiPS library were optimized using solution-phase synthesis. X-ray crystallography of inhibited complexes was used to identify substructures that coordinate to the active site zinc. The...
6.
Turek-Etienne T, Strickland C, Distefano M
Biochemistry
. 2003 Apr;
42(13):3716-24.
PMID: 12667062
Protein farnesyl transferase (PFTase) catalyzes the reaction between farnesyl diphosphate and a protein substrate to form a thioether-linked prenylated protein. The fact that many prenylated proteins are involved in signaling...
7.
Njoroge F, Vibulbhan B, Pinto P, Strickland C, Bishop W, Kirschmeir P, et al.
Bioorg Med Chem
. 2002 Dec;
11(1):139-43.
PMID: 12467716
SCH 66336 is a trihalo tricyclic compound that is currently undergoing Phase II clinical trials for the treatment of solid tumors. Modifications of SCH 66336 by incorporating such groups as...
8.
Taveras A, Aki C, Chao J, Doll R, Lalwani T, Girijavallabhan V, et al.
J Med Chem
. 2002 Aug;
45(18):3854-64.
PMID: 12190309
The 10-bromobenzocycloheptapyridyl farnesyl transferase inhibitor (FTI) Sch-66336 (1) is currently under clinical evaluation for the treatment of human cancers. During structure-activity relationship development leading to 1, 10-bromobenzocycloheptapyridyl FTIs were found...
9.
Cooper A, Strickland C, Wang J, Desai J, Kirschmeier P, Patton R, et al.
Bioorg Med Chem Lett
. 2002 Feb;
12(4):601-5.
PMID: 11844681
A series of novel N-cyanoguanidine tricyclic farnesyl protein transferase (FPT) inhibitors was prepared. Replacement of a piperidine amide-group with a N-cyanoguanidine functionality increased FPT activity. X-ray crystal structure determination of...