Christopher G Evans
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Explore the profile of Christopher G Evans including associated specialties, affiliations and a list of published articles.
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11
Citations
555
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Recent Articles
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Chafekar S, Wisen S, Thompson A, Echeverria A, Walter G, Evans C, et al.
ACS Chem Biol
. 2012 Jun;
7(9):1556-64.
PMID: 22709427
Nine neurodegenerative disorders are caused by the abnormal expansion of polyglutamine (polyQ) regions within distinct proteins. Genetic and biochemical evidence has documented that the molecular chaperone, heat shock protein 70...
3.
Evans C, Smith M, Carolan J, Gestwicki J
Bioorg Med Chem Lett
. 2011 Mar;
21(9):2587-90.
PMID: 21420295
Spergualin is a natural product that exhibits immunosuppressive, anti-tumor and anti-bacterial activities. Its derivatives, such as 15-deoxyspergualin (15-DSG), have been clinically approved for acute allograft rejection. However, the reported syntheses...
4.
Evans C, Jinwal U, Makley L, Dickey C, Gestwicki J
Chem Commun (Camb)
. 2010 Nov;
47(1):529-31.
PMID: 21082080
A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent...
5.
Wisen S, Bertelsen E, Thompson A, Patury S, Ung P, Chang L, et al.
ACS Chem Biol
. 2010 May;
5(6):611-22.
PMID: 20481474
Heat shock protein 70 (Hsp70) is a highly conserved molecular chaperone that plays multiple roles in protein homeostasis. In these various tasks, the activity of Hsp70 is shaped by interactions...
6.
Evans C, Chang L, Gestwicki J
J Med Chem
. 2010 Mar;
53(12):4585-602.
PMID: 20334364
No abstract available.
7.
Marinec P, Evans C, Gibbons G, Tarnowski M, Overbeek D, Gestwicki J
Bioorg Med Chem
. 2009 Aug;
17(16):5763-8.
PMID: 19643614
Chemical inducers of dimerization (CIDs) are employed in a wide range of biological applications to control protein localization, modulate protein-protein interactions and improve drug lifetimes. These bifunctional chemical probes are...
8.
Evans C, Gestwicki J
Org Lett
. 2009 Jun;
11(14):2957-9.
PMID: 19527003
The four-component Hantzsch reaction provides access to pharmaceutically important dihydropyridines. To expand the utility of this method, we have developed a route under organocatalytic conditions with good yields and excellent...
9.
Wisen S, Androsavich J, Evans C, Chang L, Gestwicki J
Bioorg Med Chem Lett
. 2007 Dec;
18(1):60-5.
PMID: 18060774
Molecular chaperones, such as Hsp70 and Hsp90, are responsible for a variety of protective, anti-apoptotic functions. While inhibitors of Hsp90, such as geldanamycin and its derivative 17-AAG, are well known...
10.
Evans C, Wisen S, Gestwicki J
J Biol Chem
. 2006 Sep;
281(44):33182-91.
PMID: 16973602
Alzheimer disease is a neurological disorder that is characterized by the presence of fibrils and oligomers composed of the amyloid beta (Abeta) peptide. In models of Alzheimer disease, overexpression of...