Christina Galonska
Overview
Explore the profile of Christina Galonska including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
811
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0
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Recent Articles
1.
Schmidt M, Gupta A, Bednarski C, Gehrig-Giannini S, Richter F, Pitzler C, et al.
Nat Commun
. 2023 Jun;
14(1):3503.
PMID: 37311765
No abstract available.
2.
Huang Y, Chen C, Sundaramurthy V, Slabicki M, Hao D, Watson C, et al.
Cancer Discov
. 2021 Aug;
12(1):220-235.
PMID: 34429321
Clonal hematopoiesis is a prevalent age-related condition associated with a greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A () are the most common driver of this state....
3.
Schmidt M, Gupta A, Bednarski C, Gehrig-Giannini S, Richter F, Pitzler C, et al.
Nat Commun
. 2021 Jul;
12(1):4219.
PMID: 34244505
Streptococcus pyogenes (Spy) Cas9 has potential as a component of gene therapeutics for incurable diseases. One of its limitations is its large size, which impedes its formulation and delivery in...
4.
Haggerty C, Kretzmer H, Riemenschneider C, Kumar A, Mattei A, Bailly N, et al.
Nat Struct Mol Biol
. 2021 Jun;
28(7):594-603.
PMID: 34140676
DNA methylation plays a critical role during development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities of the canonical maintenance enzyme Dnmt1 and the...
5.
Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling
Huyghe A, Furlan G, Ozmadenci D, Galonska C, Charlton J, Gaume X, et al.
Nat Cell Biol
. 2020 Apr;
22(4):389-400.
PMID: 32231305
In mouse embryonic stem cells (mESCs), chemical blockade of Gsk3α/β and Mek1/2 (2i) instructs a self-renewing ground state whose endogenous inducers are unknown. Here we show that the axon guidance...
6.
Giesselmann P, Brandl B, Raimondeau E, Bowen R, Rohrandt C, Tandon R, et al.
Nat Biotechnol
. 2019 Nov;
37(12):1478-1481.
PMID: 31740840
Expansions of short tandem repeats are genetic variants that have been implicated in several neuropsychiatric and other disorders, but their assessment remains challenging with current polymerase-based methods. Here we introduce...
7.
Shukla S, Bachireddy P, Schilling B, Galonska C, Zhan Q, Bango C, et al.
Cell
. 2018 Apr;
173(3):624-633.e8.
PMID: 29656892
CTLA-4 immune checkpoint blockade is clinically effective in a subset of patients with metastatic melanoma. We identify a subcluster of MAGE-A cancer-germline antigens, located within a narrow 75 kb region...
8.
Ziller M, Ortega J, Quinlan K, Santos D, Gu H, Martin E, et al.
Cell Stem Cell
. 2018 Mar;
22(4):559-574.e9.
PMID: 29551301
The somatic DNA methylation (DNAme) landscape is established early in development but remains highly dynamic within focal regions that overlap with gene regulatory elements. The significance of these dynamic changes,...
9.
Galonska C, Charlton J, Mattei A, Donaghey J, Clement K, Gu H, et al.
Nat Commun
. 2018 Feb;
9(1):597.
PMID: 29426832
In normal mammalian development cytosine methylation is essential and is directed to specific regions of the genome. Despite notable advances through mapping its genome-wide distribution, studying the direct contribution of...
10.
Galonska C, Ziller M, Karnik R, Meissner A
Cell Stem Cell
. 2015 Aug;
17(4):462-70.
PMID: 26235340
Mouse embryonic stem cells (mESCs) cultured under serum/LIF conditions exhibit heterogeneous expression of pluripotency-associated factors that can be overcome by two inhibitors (2i) of the MEK and GSK3 pathways. Several...