Christian Melander
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Explore the profile of Christian Melander including associated specialties, affiliations and a list of published articles.
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150
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2794
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Recent Articles
1.
Hondros A, Young M, Jaimes F, Kinkead J, Thompson R, Melander C, et al.
Biochemistry
. 2025 Mar;
PMID: 40056100
Two-component systems serve as ubiquitous communication modules that enable bacteria to detect and respond to various stimuli by regulating cellular processes such as growth, viability, and, most notably, antimicrobial resistance....
2.
Butman H, Stefaniak M, Walsh D, Gondil V, Young M, Crow A, et al.
Bioorg Med Chem Lett
. 2025 Mar;
121:130164.
PMID: 40043820
Penicillin binding protein 4 (PBP4) is essential for Staphylococcus aureus cortical bone osteocyte lacuno-canalicular network (OLCN) invasion, which causes osteomyelitis and serves as a bacterial niche for recurring bone infection....
3.
Koller B, Jania L, Li H, Barker W, Melander R, Melander C
Antimicrob Agents Chemother
. 2024 Aug;
68(10):e0067124.
PMID: 39194205
Antimicrobial resistance (AMR) has led to a marked reduction in the effectiveness of many antibiotics, representing a substantial and escalating concern for global health. Particularly alarming is resistance in Gram-negative...
4.
Gondil V, Butman H, Young M, Walsh D, Narkhede Y, Zeiler M, et al.
Chem Biol Drug Des
. 2024 Jun;
103(6):e14569.
PMID: 38877369
Staphylococcus aureus has the ability to invade cortical bone osteocyte lacuno-canalicular networks (OLCNs) and cause osteomyelitis. It was recently established that the cell wall transpeptidase, penicillin-binding protein 4 (PBP4), is...
5.
Li H, Nemeth A, Melander R, Melander C
ACS Infect Dis
. 2024 Mar;
10(4):1339-1350.
PMID: 38491938
Increasing antimicrobial resistance, coupled with the absence of new antibiotics, has led physicians to rely on colistin, a polymyxin with known nephrotoxicity, as the antibiotic of last resort for the...
6.
Nemeth A, Young M, Melander R, Smith R, Ernst R, Melander C
Chembiochem
. 2024 Mar;
25(8):e202400127.
PMID: 38451872
The development of novel therapeutic approaches is crucial in the fight against multi-drug resistant (MDR) bacteria, particularly gram-negative species. Small molecule adjuvants that enhance the activity of otherwise gram-positive selective...
7.
Crotteau A, Hubble V, Marrujo S, Mattingly A, Melander R, Melander C
Antibiotics (Basel)
. 2023 Nov;
12(11).
PMID: 37998765
In 2019, five million deaths associated with antimicrobial resistance were reported by The Centers for Disease Control and Prevention (CDC). , a Gram-negative bacterial pathogen, is among the list of...
8.
Bennett A, Woolard K, Sorge A, Melander C, Gunn J
Biofilm
. 2023 Oct;
6:100158.
PMID: 37790732
The ESKAPE pathogens are a group of bacteria that are a leading cause of health-care associated infections and are known to be agents of chronic, biofilm-mediated infections. These chronic bacterial...
9.
Harper E, Siroky M, Hilliard T, Dominique G, Hammond C, Liu Y, et al.
Int J Mol Sci
. 2023 Jun;
24(12).
PMID: 37372952
Ovarian cancer is the sixth leading cause of cancer-related death in women, and both occurrence and mortality are increased in women over the age of 60. There are documented age-related...
10.
Jenul C, Keim K, Jens J, Zeiler M, Schilcher K, Schurr M, et al.
Cell Rep
. 2023 May;
42(6):112540.
PMID: 37227819
Pseudomonas aeruginosa and Staphylococcus aureus are among the most frequently isolated bacterial species from polymicrobial infections of patients with cystic fibrosis and chronic wounds. We apply mass spectrometry guided interaction...