Robert W Huigens 3rd
Overview
Explore the profile of Robert W Huigens 3rd including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
48
Citations
875
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Schultz D, Chavez-Riveros A, Goertzen 2nd M, Brummel B, Paes R, Santos N, et al.
Org Biomol Chem
. 2024 Aug;
22(42):8423-8436.
PMID: 39113550
Natural product ring distortion strategies have enabled rapid access to unique libraries of stereochemically complex compounds to explore new chemical space and increase our understanding of biological processes related to...
2.
Leas D, Schultz D, Huigens 3rd R
SynOpen
. 2023 Oct;
7(2):165-185.
PMID: 37795132
This graphical review provides a concise overview of indole alkaloids and chemical reactions that have been reported to transform both these natural products and derivatives to rapidly access new molecular...
3.
Liu K, Xiao T, Yang H, Chen M, Gao Q, Brummel B, et al.
RSC Med Chem
. 2023 Aug;
14(8):1472-1481.
PMID: 37593580
It is of great importance to develop new strategies to combat antibiotic resistance. Our lab has discovered halogenated phenazine (HP) analogues that are highly active against multidrug-resistant bacterial pathogens. Here,...
4.
Guijarro M, Kellish P, Dib P, Paciaroni N, Nawab A, Andring J, et al.
JCI Insight
. 2023 Apr;
8(10).
PMID: 37097751
Although thymidylate synthase (TYMS) inhibitors have served as components of chemotherapy regimens, the currently available inhibitors induce TYMS overexpression or alter folate transport/metabolism feedback pathways that tumor cells exploit for...
5.
Xiao T, Liu K, Gao Q, Chen M, Kim Y, Jin S, et al.
ACS Infect Dis
. 2023 Mar;
9(4):899-915.
PMID: 36867688
Pathogenic bacteria have devastating impacts on human health as a result of acquired antibiotic resistance and innate tolerance. Every class of our current antibiotic arsenal was initially discovered as growth-inhibiting...
6.
Jenquin J, OBrien A, Poukalov K, Lu Y, Frias J, Shorrock H, et al.
iScience
. 2022 Apr;
25(5):104198.
PMID: 35479399
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are common forms of adult onset muscular dystrophy. Pathogenesis in both diseases is largely driven by production of toxic-expanded repeat RNAs...
7.
Huigens 3rd R, Brummel B, Tenneti S, Garrison A, Xiao T
Molecules
. 2022 Feb;
27(3).
PMID: 35164376
There are numerous pyrazine and phenazine compounds that demonstrate biological activities relevant to the treatment of disease. In this review, we discuss pyrazine and phenazine agents that have shown potential...
8.
Liu K, Brivio M, Xiao T, Norwood 4th V, Kim Y, Jin S, et al.
ACS Infect Dis
. 2022 Jan;
8(2):280-295.
PMID: 35089005
During infection, bacteria use an arsenal of resistance mechanisms to negate antibiotic therapies. In addition, pathogenic bacteria form surface-attached biofilms bearing enriched populations of metabolically dormant persister cells. Bacteria develop...
9.
Yang H, Kundra S, Chojnacki M, Liu K, Fuse M, Abouelhassan Y, et al.
J Med Chem
. 2021 Apr;
64(11):7275-7295.
PMID: 33881312
Pathogenic bacteria demonstrate incredible abilities to evade conventional antibiotics through the development of resistance and formation of dormant, surface-attached biofilms. Therefore, agents that target and eradicate planktonic and biofilm bacteria...
10.
Fu T, Cai Z, Yue Z, Yang H, Fang B, Zhang X, et al.
ACS Infect Dis
. 2021 Mar;
7(3):636-649.
PMID: 33650853
In the niches that and coinhabit, the later pathogen produces phenazine antibiotics to inhibit the growth of . Recently, a group of halogenated phenazines (HPs) has been shown to have...