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John Cavanagh

Explore the profile of John Cavanagh including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 70
Citations 881
Followers 0
Related Specialties
Biochemistry
Molecular Biology
Microbiology
Top 10 Co-Authors
Richele J Thompson
Benjamin G Bobay
Christian Melander
Morgan E Milton
Andrew L Olson
Douglas J Kojetin
Richele Thompson
Stephen Naylor
Ashley T Tucker
Sean D Stowe
Published In
Biochemistry
J Mol Biol
FEBS Lett
Biomol NMR Assign
Biochem Biophys Res Commun
Affiliations
Soon will be listed here.
Recent Articles
1.
Two-Component System Sensor Kinase Inhibitors Target the ATP-Lid of PmrB to Disrupt Colistin Resistance in
Hondros A, Young M, Jaimes F, Kinkead J, Thompson R, Melander C, et al.
Biochemistry . 2025 Mar; PMID: 40056100
Two-component systems serve as ubiquitous communication modules that enable bacteria to detect and respond to various stimuli by regulating cellular processes such as growth, viability, and, most notably, antimicrobial resistance....
2.
Insights into DNA-binding motifs and mechanisms of Francisella tularensis novicida two-component system response regulator proteins QseB, KdpE, and BfpR
Gaddy K, Bensch E, Cavanagh J, Milton M
Biochem Biophys Res Commun . 2024 May; 722:150150. PMID: 38805787
Two component system bacterial response regulators are typically DNA-binding proteins which enable the genetic regulation of many adaptive bacterial behaviors. Despite structural similarity across response regulator families, there is a...
3.
The Biofilm Regulatory Network from Bacillus subtilis: A Structure-Function Analysis
Milton M, Cavanagh J
J Mol Biol . 2022 Dec; 435(3):167923. PMID: 36535428
Bacterial biofilms are notorious for their ability to protect bacteria from environmental challenges, most importantly the action of antibiotics. Bacillus subtilis is an extensively studied model organism used to understand...
4.
2-Aminoimidazole Analogs Target PhoP Altering DNA Binding Activity and Affect Outer Membrane Stability in Gram-Negative Bacteria
Zeczycki T, Milton M, Jung D, Thompson R, Jaimes F, Hondros A, et al.
Biochemistry . 2022 Dec; 61(24):2948-2960. PMID: 36454711
Multidrug-resistant bacteria cause immense public health concerns as once effective antibiotics no longer work against even common infections. Concomitantly, there has been a decline in the discovery of new antibiotics,...
5.
Acinetobacter baumannii Regulates Its Stress Responses via the BfmRS Two-Component Regulatory System
Palethorpe S, Farrow 3rd J, Wells G, Milton M, Actis L, Cavanagh J, et al.
J Bacteriol . 2021 Dec; 204(2):e0049421. PMID: 34871031
Acinetobacter baumannii is a common nosocomial pathogen that utilizes numerous mechanisms to aid its survival in both the environment and the host. Coordination of such mechanisms requires an intricate regulatory...
6.
Structure of the Acinetobacter baumannii PmrA receiver domain and insights into clinical mutants affecting DNA binding and promoting colistin resistance
Palethorpe S, Milton M, Pesci E, Cavanagh J
J Biochem . 2021 Sep; 170(6):787-800. PMID: 34585233
Acinetobacter baumannii is an insidious emerging nosocomial pathogen that has developed resistance to all available antimicrobials, including the last resort antibiotic, colistin. Colistin resistance often occurs due to mutations in...
7.
Two-Component System Response Regulator BfpR Modulates iglC Gene Expression, Antimicrobial Peptide Resistance, and Biofilm Production
Dean S, Milton M, Cavanagh J, van Hoek M
Front Cell Infect Microbiol . 2020 Apr; 10:82. PMID: 32232010
Response regulators are a critical part of the two-component system of gene expression regulation in bacteria, transferring a signal from a sensor kinase into DNA binding activity resulting in alteration...
8.
The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis
Milton M, Draughn G, Bobay B, Stowe S, Olson A, Feldmann E, et al.
J Mol Biol . 2019 Sep; 432(2):343-357. PMID: 31493408
Bacteria have developed numerous protection strategies to ensure survival in harsh environments, with perhaps the most robust method being the formation of a protective biofilm. In biofilms, bacterial cells are...
9.
Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from and QseB from spp
Milton M, Minrovic B, Harris D, Kang B, Jung D, Lewis C, et al.
Front Mol Biosci . 2018 Mar; 5:15. PMID: 29487854
2-aminoimidazole (2-AI) compounds inhibit the formation of bacterial biofilms, disperse preformed biofilms, and re-sensitize multidrug resistant bacteria to antibiotics. 2-AIs have previously been shown to interact with bacterial response regulators,...
10.
The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism
Draughn G, Milton M, Feldmann E, Bobay B, Roth B, Olson A, et al.
J Mol Biol . 2018 Feb; 430(6):806-821. PMID: 29438671
The rise of drug-resistant bacterial infections coupled with decreasing antibiotic efficacy poses a significant challenge to global health care. Acinetobacter baumannii is an insidious, emerging bacterial pathogen responsible for severe...