Christian C Dibble
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Explore the profile of Christian C Dibble including associated specialties, affiliations and a list of published articles.
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24
Citations
3044
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Recent Articles
11.
Toker A, Dibble C
Mol Cell
. 2018 Sep;
71(6):875-876.
PMID: 30241602
In this issue of Molecular Cell, Liu et al. (2018) show that PI34P2 and PIP3, the lipid products of class I phosphoinositide 3-kinase (PI3K), display distinct spatiotemporal kinetics in cells...
12.
Lien E, Dibble C, Toker A
Curr Opin Cell Biol
. 2017 Mar;
45:62-71.
PMID: 28343126
The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most frequently altered pathways in human cancer and has a critical role in driving tumor initiation and progression. Although PI3K...
13.
Ricoult S, Dibble C, Asara J, Manning B
Mol Cell Biol
. 2016 Jun;
36(18):2384-95.
PMID: 27354064
Sterol regulatory element binding protein (SREBP) is a major transcriptional regulator of the enzymes underlying de novo lipid synthesis. However, little is known about the SREBP-mediated control of processes that...
14.
Dibble C, Cantley L
Trends Cell Biol
. 2015 Jul;
25(9):545-55.
PMID: 26159692
The class I phosphoinositide 3-kinase (PI3K)-mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation of mTORC1 [composed of mTOR, regulatory-associated protein of mTOR...
15.
Menon S, Dibble C, Talbott G, Hoxhaj G, Valvezan A, Takahashi H, et al.
Cell
. 2014 Feb;
156(4):771-85.
PMID: 24529379
mTORC1 promotes cell growth in response to nutrients and growth factors. Insulin activates mTORC1 through the PI3K-Akt pathway, which inhibits the TSC1-TSC2-TBC1D7 complex (the TSC complex) to turn on Rheb,...
16.
Dibble C, Manning B
Nat Cell Biol
. 2013 Jun;
15(6):555-64.
PMID: 23728461
Flux through metabolic pathways is inherently sensitive to the levels of specific substrates and products, but cellular metabolism is also managed by integrated control mechanisms that sense the nutrient and...
17.
Dibble C, Elis W, Menon S, Qin W, Klekota J, Asara J, et al.
Mol Cell
. 2012 Jul;
47(4):535-46.
PMID: 22795129
The tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 complex, which limits cell growth in response to poor growth conditions. Through its GTPase-activating protein (GAP) activity toward Rheb, this...
18.
Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, et al.
Cancer Discov
. 2011 Dec;
1(6):524-38.
PMID: 22145100
Unlabelled: Although it is known that mTOR complex 2 (mTORC2) functions upstream of Akt, the role of this protein kinase complex in cancer is not well understood. Through an integrated...
19.
Dibble C, Manning B
Cancer Cell
. 2009 Sep;
16(3):178-80.
PMID: 19732717
The protein kinase AKT is frequently activated in human cancers and has been implicated in resistance to chemotherapy. In this issue of Cancer Cell, Pei et al. show that FKBP51...
20.
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
Dibble C, Asara J, Manning B
Mol Cell Biol
. 2009 Sep;
29(21):5657-70.
PMID: 19720745
The mammalian target of rapamycin (mTOR) functions within two distinct complexes (mTORC1 and mTORC2) to control cell growth, proliferation, survival, and metabolism. While there has been great progress in our...