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A Molecular Link Between AKT Regulation and Chemotherapeutic Response

Overview
Journal Cancer Cell
Publisher Cell Press
Specialty Oncology
Date 2009 Sep 8
PMID 19732717
Citations 15
Authors
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Abstract

The protein kinase AKT is frequently activated in human cancers and has been implicated in resistance to chemotherapy. In this issue of Cancer Cell, Pei et al. show that FKBP51 negatively regulates AKT through the phosphatase PHLPP. This regulation appears to be a determinant of chemosensitivity in cancer cells.

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