Brendan D Manning
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Explore the profile of Brendan D Manning including associated specialties, affiliations and a list of published articles.
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101
Citations
20158
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Recent Articles
1.
Cormerais Y, Lapp S, Kalafut K, Cisse M, Shin J, Stefadu B, et al.
bioRxiv
. 2024 Oct;
PMID: 39386441
Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates diverse intracellular and extracellular growth signals to regulate cell and tissue growth. How the molecular mechanisms regulating mTORC1 signaling established through...
2.
Manning B, Dibble C
Cold Spring Harb Perspect Med
. 2024 Mar;
14(10).
PMID: 38438221
Normal cells grow and divide only when instructed to by signaling pathways stimulated by exogenous growth factors. A nearly ubiquitous feature of cancer cells is their capacity to grow independent...
3.
Zhang H, Lipovsky A, Dibble C, Sahin M, Manning B
Mol Cell
. 2023 Sep;
83(17):3217.
PMID: 37683612
No abstract available.
4.
Hosios A, Wilkinson M, McNamara M, Kalafut K, Torrence M, Asara J, et al.
Nat Metab
. 2022 Dec;
4(12):1792-1811.
PMID: 36536136
The mechanistic target of rapamycin complex 1 (mTORC1) senses and relays environmental signals from growth factors and nutrients to metabolic networks and adaptive cellular systems to control the synthesis and...
5.
McNamara M, Hosios A, Torrence M, Zhao T, Fraser C, Wilkinson M, et al.
iScience
. 2022 Nov;
25(11):105458.
PMID: 36388985
mTORC1 is aberrantly activated in cancer and in the genetic tumor syndrome tuberous sclerosis complex (TSC), which is caused by loss-of-function mutations in the TSC complex, a negative regulator of...
6.
Yuskaitis C, Modasia J, Schrotter S, Rossitto L, Groff K, Morici C, et al.
Cell Rep
. 2022 Aug;
40(9):111278.
PMID: 36044864
Caloric restriction and acute fasting are known to reduce seizures but through unclear mechanisms. mTOR signaling has been suggested as a potential mechanism for seizure protection from fasting. We demonstrate...
7.
Schrotter S, Yuskaitis C, MacArthur M, Mitchell S, Hosios A, Osipovich M, et al.
Cell Rep
. 2022 May;
39(7):110824.
PMID: 35584673
The tuberous sclerosis complex (TSC) 1 and 2 proteins associate with TBC1D7 to form the TSC complex, which is an essential suppressor of mTOR complex 1 (mTORC1), a ubiquitous driver...
8.
Soflaee M, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, et al.
Nat Commun
. 2022 May;
13(1):2698.
PMID: 35577785
Purine nucleotides are necessary for various biological processes related to cell proliferation. Despite their importance in DNA and RNA synthesis, cellular signaling, and energy-dependent reactions, the impact of changes in...
9.
Tee A, Manning B, Roux P, Cantley L, Blenis J
Curr Biol
. 2022 Feb;
32(3):733-734.
PMID: 35134350
No abstract available.
10.
Hosios A, Manning B
Cancer Res
. 2021 Oct;
81(19):4896-4898.
PMID: 34598998
The Warburg effect, the propensity of some cells to metabolize glucose to lactate in the presence of oxygen (also known as aerobic glycolysis), has long been observed in cancer and...