Christian C Dibble
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Explore the profile of Christian C Dibble including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
3044
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Recent Articles
1.
Barritt S, DuBois-Coyne S, Dibble C
Nat Metab
. 2024 Jun;
6(6):1008-1023.
PMID: 38871981
The tricarboxylic acid cycle, nutrient oxidation, histone acetylation and synthesis of lipids, glycans and haem all require the cofactor coenzyme A (CoA). Although the sources and regulation of the acyl...
2.
Manning B, Dibble C
Cold Spring Harb Perspect Med
. 2024 Mar;
14(10).
PMID: 38438221
Normal cells grow and divide only when instructed to by signaling pathways stimulated by exogenous growth factors. A nearly ubiquitous feature of cancer cells is their capacity to grow independent...
3.
Crawford M, Tripu D, Barritt S, Jing Y, Gallimore D, Kales S, et al.
ACS Chem Biol
. 2023 Sep;
18(10):2249-2258.
PMID: 37737090
The human acetyltransferase paralogues EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicated in various cancers. In the half-decade since the first drug-like inhibitors of...
4.
Zhang H, Lipovsky A, Dibble C, Sahin M, Manning B
Mol Cell
. 2023 Sep;
83(17):3217.
PMID: 37683612
No abstract available.
5.
Zhang T, Xu D, Trefts E, Lv M, Inuzuka H, Song G, et al.
Science
. 2023 Jun;
380(6652):1372-1380.
PMID: 37384704
Adenosine monophosphate-activated protein kinase (AMPK) activity is stimulated to promote metabolic adaptation upon energy stress. However, sustained metabolic stress may cause cell death. The mechanisms by which AMPK dictates cell...
6.
Crawford M, Tripu D, Barritt S, Jing Y, Gallimore D, Kales S, et al.
bioRxiv
. 2023 Jun;
PMID: 37292747
The human acetyltransferase paralogs EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicated in various cancers. In the half-decade since the first drug-like inhibitors of...
7.
Dibble C, Barritt S, Perry G, Lien E, Geck R, DuBois-Coyne S, et al.
Nature
. 2022 Jul;
608(7921):192-198.
PMID: 35896750
In response to hormones and growth factors, the class I phosphoinositide-3-kinase (PI3K) signalling network functions as a major regulator of metabolism and growth, governing cellular nutrient uptake, energy generation, reducing...
8.
Jouandin P, Marelja Z, Shih Y, Parkhitko A, Dambowsky M, Asara J, et al.
Science
. 2022 Feb;
375(6582):eabc4203.
PMID: 35175796
Adaptation to nutrient scarcity involves an orchestrated response of metabolic and signaling pathways to maintain homeostasis. We find that in the fat body of fasting , lysosomal export of cystine...
9.
Kang Y, Torrente L, Falzone A, Elkins C, Liu M, Asara J, et al.
Elife
. 2019 Oct;
8.
PMID: 31625908
No abstract available.
10.
Kang Y, Torrente L, Falzone A, Elkins C, Liu M, Asara J, et al.
Elife
. 2019 May;
8.
PMID: 31107239
NRF2 is emerging as a major regulator of cellular metabolism. However, most studies have been performed in cancer cells, where co-occurring mutations and tumor selective pressures complicate the influence of...