Charlotta S Olofsson
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Explore the profile of Charlotta S Olofsson including associated specialties, affiliations and a list of published articles.
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34
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751
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Recent Articles
1.
Lovfors W, Magnusson R, Jonsson C, Gustafsson M, Olofsson C, Cedersund G, et al.
NPJ Syst Biol Appl
. 2023 Jun;
9(1):24.
PMID: 37286693
Adipocyte signaling, normally and in type 2 diabetes, is far from fully understood. We have earlier developed detailed dynamic mathematical models for several well-studied, partially overlapping, signaling pathways in adipocytes....
2.
Cinato M, Mardani I, Miljanovic A, Drevinge C, Laudette M, Bollano E, et al.
Life Sci Alliance
. 2023 Jan;
6(4).
PMID: 36717246
The adult heart develops hypertrophy to reduce ventricular wall stress and maintain cardiac function in response to an increased workload. Although pathological hypertrophy generally progresses to heart failure, physiological hypertrophy...
3.
Paul A, Chanclon B, Brannmark C, Wittung-Stafshede P, Olofsson C, Asterholm I, et al.
J Cell Biochem
. 2023 Jan;
124(3):382-395.
PMID: 36715685
Brown adipose tissue (BAT) consists of highly metabolically active adipocytes that catabolize nutrients to produce heat. Playing an active role in triacylglycerol (TAG) clearance, research has shown that dietary fatty...
4.
Eerola K, Longo F, Reinbothe T, Richard J, Shevchouk O, Lopez-Ferreras L, et al.
Mol Metab
. 2022 Oct;
66:101614.
PMID: 36244663
Objective: Pancreatic insulin was discovered a century ago, and this discovery led to the first lifesaving treatment for diabetes. While still controversial, nearly one hundred published reports suggest that insulin...
5.
Bauza-Thorbrugge M, Banke E, Chanclon B, Peris E, Wu Y, Musovic S, et al.
Mol Metab
. 2022 Jun;
63:101535.
PMID: 35760318
Objective: Sarco/endoplasmic reticulum Ca-ATPase (SERCA) transports Ca from the cytosol into the endoplasmic retitculum (ER) and is essential for appropriate regulation of intracellular Ca homeostasis. The objective of this study...
6.
Musovic S, Komai A, Said M, Mohan Shrestha M, Wu Y, Asterholm I, et al.
Mol Cell Endocrinol
. 2022 Mar;
549:111619.
PMID: 35337901
White adipocyte adiponectin exocytosis is triggered by cAMP and a concomitant increase of cytosolic Ca potentiates its release. White adipose tissue is richly innervated by sympathetic nerves co-releasing noradrenaline (NA)...
7.
Lovfors W, Simonsson C, Komai A, Nyman E, Olofsson C, Cedersund G
J Biol Chem
. 2021 Oct;
297(5):101221.
PMID: 34597667
Circulating levels of the adipocyte hormone adiponectin are typically reduced in obesity, and this deficiency has been linked to metabolic diseases. It is thus important to understand the mechanisms controlling...
8.
Musovic S, Mohan Shrestha M, Komai A, Olofsson C
Biochem Biophys Res Commun
. 2020 Dec;
534:707-713.
PMID: 33261886
In the current work we have investigated the cellular and molecular regulation of resistin secretion in cultured and primary mouse adipocytes. Resistin is an adipose tissue hormone proposed to contribute...
9.
Komai A, Mohan Shrestha M, Musovic S, Olofsson C
Methods Mol Biol
. 2020 Nov;
2233:203-222.
PMID: 33222137
Exocytosis, the fusion of vesicles with the plasma membrane, can be measured with the patch-clamp technique as increases in membrane capacitance. Here we provide detailed information on how to monitor...
10.
Brannmark C, Kay E, Ortegren Kugelberg U, Chanclon B, Mohan Shrestha M, Asterholm I, et al.
J Endocrinol
. 2020 Jul;
247(1):25-38.
PMID: 32668406
Here we have investigated the role of the protein caveolin 1 (Cav1) and caveolae in the secretion of the white adipocyte hormone adiponectin. Using mouse primary subcutaneous adipocytes genetically depleted...