Charles J Bieberich
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Explore the profile of Charles J Bieberich including associated specialties, affiliations and a list of published articles.
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51
Citations
1581
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Recent Articles
1.
Waters 3rd C, Carlyle E, Smart V, Rege A, Bieberich C, Seley-Radtke K
Bioorg Med Chem
. 2024 Aug;
112:117898.
PMID: 39216384
In this study, proximal fleximer nucleos(t)ide analogues of Bemnifosbuvir were synthesized and evaluated for their potential to serve as antiviral therapeutics. The final parent flex-nucleoside and ProTide modified flex-nucleoside analogues...
2.
Graham M, Wang R, Chikarmane R, Abel B, Vaghasia A, Gupta A, et al.
Nat Commun
. 2024 Aug;
15(1):7414.
PMID: 39198404
How prostate cancer cells and their precursors mediate changes in the tumor microenvironment (TME) to drive prostate cancer progression is unclear, in part due to the inability to longitudinally study...
3.
Phulara N, Rege A, Bieberich C, Seneviratne H
ACS Pharmacol Transl Sci
. 2024 Aug;
7(8):2379-2390.
PMID: 39156742
Efavirenz (EFV) is a commonly used drug to treat human immunodeficiency virus infection and is known to exert adverse effects on the brain. Although it is known that EFV is...
4.
Joglekar T, Chin A, Voskanian-Kordi A, Baek S, Raja A, Rege A, et al.
Blood Adv
. 2024 May;
8(15):3880-3892.
PMID: 38739710
Provirus integration site for Moloney murine leukemia virus (PIM) family serine/threonine kinases perform protumorigenic functions in hematologic malignancies and solid tumors by phosphorylating substrates involved in tumor metabolism, cell survival,...
5.
Graham M, Wang R, Chikarmane R, Wodu B, Vaghasia A, Gupta A, et al.
bioRxiv
. 2023 Oct;
PMID: 37905029
The tissue microenvironment in prostate cancer is profoundly altered. While such alterations have been implicated in driving prostate cancer initiation and progression to aggressive disease, how prostate cancer cells and...
6.
Chin A, Bieberich C, Stewart T, Casero Jr R
Med Sci (Basel)
. 2022 Jun;
10(2).
PMID: 35736351
Polyamine biosynthesis is frequently dysregulated in cancers, and enhanced flux increases intracellular polyamines necessary for promoting cell growth, proliferation, and function. Polyamine depletion strategies demonstrate efficacy in reducing tumor growth...
7.
Lopez-Bujanda Z, Haffner M, Chaimowitz M, Chowdhury N, Venturini N, Patel R, et al.
Nat Cancer
. 2022 Feb;
2(8):803-818.
PMID: 35122025
Unlike several other tumor types, prostate cancer rarely responds to immune checkpoint blockade (ICB). To define tumor cell intrinsic factors that contribute to prostate cancer progression and resistance to ICB,...
8.
Maisha N, Rubenstein M, Bieberich C, Lavik E
Nano Lett
. 2021 Oct;
21(21):9069-9076.
PMID: 34714087
One of the significant challenges to translation of intravenously administered nanomaterials has been complement-mediated infusion reactions which can be lethal. Slow infusions can reduce infusion reactions, but slow infusions are...
9.
Gu Q, Dockery L, Daniel M, Bieberich C, Ma R, Zhu L
Fluids (Basel)
. 2021 Oct;
6(8).
PMID: 34651038
This work discusses in vivo experiments that were performed to evaluate whether local or whole-body heating to 40 °C reduced interstitial fluid pressures (IFPs) and enhanced nanoparticle delivery to subcutaneous...
10.
Lin Y, Wang Y, Ding J, Jiang A, Wang J, Yu M, et al.
Sci Transl Med
. 2021 Jun;
13(599).
PMID: 34162754
Increasing clinical evidence has demonstrated that the deletion or mutation of tumor suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in cancer cells...