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Jessica L Hicks

Explore the profile of Jessica L Hicks including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 76
Citations 3196
Followers 0
Related Specialties
Pathology
Oncology
General Medicine
Top 10 Co-Authors
Angelo M De Marzo
Srinivasan Yegnasubramanian
Alan K Meeker
Qizhi Zheng
Tamara L Lotan
William G Nelson
Tracy Jones
Elizabeth A Platz
Jonathan I Epstein
William B Isaacs
Published In
Am J Pathol
Prostate
Mod Pathol
Clin Cancer Res
Cancer Res
Affiliations
Soon will be listed here.
Recent Articles
1.
Association of glutaminase expression with immune-suppressive tumor microenvironment, clinicopathologic features, and clinical outcomes in endometrial cancer
Asaka S, Verma N, Yen T, Hicks J, Nonogaki H, Shen Y, et al.
Int J Gynecol Cancer . 2024 Oct; 34(11):1737-1744. PMID: 39414312
Objective: Increased glutamine metabolism by cancer cells via upregulation of the drug-targetable enzyme glutaminase may contribute to an immune-suppressive tumor microenvironment. Inhibiting glutamine metabolism can not only suppress tumor growth,...
2.
Comparison of Pathologist and Artificial Intelligence-based Grading for Prediction of Metastatic Outcomes After Radical Prostatectomy
Oliveira L, Lu J, Erak E, Mendes A, Dairo O, Ertunc O, et al.
Eur Urol Oncol . 2024 Sep; 8(1):9-13. PMID: 39232875
Gleason grade group (GG) is the most powerful prognostic variable in localized prostate cancer; however, interobserver variability remains a challenge. Artificial intelligence algorithms applied to histopathologic images standardize grading, but...
3.
Overexpression of Fibroblast Activation Protein (FAP) in stroma of proliferative inflammatory atrophy (PIA) and primary adenocarcinoma of the prostate
Caramella-Pereira F, Zheng Q, Hicks J, Roy S, Jones T, Pomper M, et al.
medRxiv . 2024 Apr; PMID: 38633791
Fibroblast activation protein (FAP) is a serine protease upregulated at sites of tissue remodeling and cancer that represents a promising therapeutic and molecular imaging target. In prostate cancer, studies of...
4.
MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression
Chen J, Zheng Q, Hicks J, Trabzonlu L, Ozbek B, Jones T, et al.
JCI Insight . 2023 Nov; 8(24). PMID: 37971875
Increased mitochondrial function may render some cancers vulnerable to mitochondrial inhibitors. Since mitochondrial function is regulated partly by mitochondrial DNA copy number (mtDNAcn), accurate measurements of mtDNAcn could help reveal...
5.
Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate
Ertunc O, Smearman E, Zheng Q, Hicks J, Brosnan-Cashman J, Jones T, et al.
Prostate . 2023 Oct; 84(2):148-157. PMID: 37849074
Background: Telomeres are terminal chromosomal elements that are essential for the maintenance of genomic integrity. The measurement of telomere content provides useful diagnostic and prognostic information, and fluorescent methods have...
6.
Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer
Gupta H, Inoue H, Nakai Y, Nakayama M, Jones T, Hicks J, et al.
Cancer Prev Res (Phila) . 2023 Jun; 16(8):449-460. PMID: 37347938
Prevention Relevance: DNA hypermethylation at the GSTP1 promoter progressively spreads from being unmethylated in normal prostate to intermediate levels in precursor lesions to extensive methylation in cancer. This molecular progression...
7.
Predicting Prostate Cancer Molecular Subtype With Deep Learning on Histopathologic Images
Erak E, DePaula Oliveira L, Mendes A, Dairo O, Ertunc O, Kulac I, et al.
Mod Pathol . 2023 Jun; 36(10):100247. PMID: 37307876
Microscopic examination of prostate cancer has failed to reveal a reproducible association between molecular and morphologic features. However, deep-learning algorithms trained on hematoxylin and eosin (H&E)-stained whole slide images (WSI)...
8.
Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate
Ertunc O, Smearman E, Zheng Q, Hicks J, Brosnan-Cashman J, Jones T, et al.
bioRxiv . 2023 Apr; PMID: 37066381
Telomeres are terminal chromosomal elements that are essential for the maintenance of genomic integrity. The measurement of telomere content provides useful diagnostic and prognostic information, and fluorescent methods have been...
9.
MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression
Chen J, Zheng Q, Hicks J, Trabzonlu L, Ozbek B, Jones T, et al.
bioRxiv . 2023 Mar; PMID: 36865273
Increased mitochondrial function may render some cancers vulnerable to mitochondrial inhibitors. Since mitochondrial function is regulated partly by mitochondrial DNA copy number (mtDNAcn), accurate measurements of mtDNAcn could help reveal...
10.
Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC
Sena L, Kumar R, Sanin D, Thompson E, Rosen D, Dalrymple S, et al.
J Clin Invest . 2022 Oct; 132(23). PMID: 36194476
Testosterone is the canonical growth factor of prostate cancer but can paradoxically suppress its growth when present at supraphysiological levels. We have previously demonstrated that the cyclical administration of supraphysiological...