Srinivasan Yegnasubramanian
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Explore the profile of Srinivasan Yegnasubramanian including associated specialties, affiliations and a list of published articles.
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168
Citations
7661
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Recent Articles
1.
Azad T, Ran K, Materi J, Raj D, Al-Khindi T, Gabbita S, et al.
J Clin Invest
. 2025 Mar;
135(5).
PMID: 40026254
BACKGROUNDRapid diagnosis to facilitate urgent intervention is critical for treatment of acute spinal cord injury (SCI). We hypothesized that a multi-analyte blood biomarker would support point-of-care SCI diagnosis, correlate with...
2.
Tejwani V, Wang R, Villabona-Rueda A, Suresh K, Wu T, Adcock I, et al.
Am J Physiol Lung Cell Mol Physiol
. 2025 Jan;
328(3):L372-L378.
PMID: 39868576
Obesity is a risk factor for asthma morbidity, associated with less responsiveness to inhaled corticosteroids. CD4+ T cells are central to the immunology of asthma and may contribute to the...
3.
Jackson C, Cherry C, Bom S, Dykema A, Wang R, Thompson E, et al.
Science
. 2025 Jan;
387(6731):eabm5214.
PMID: 39818911
The role of glioma-associated myeloid cells in tumor growth and immune evasion remains poorly understood. We performed single-cell RNA sequencing of immune and tumor cells from 33 gliomas, identifying two...
4.
Montagne J, Mitchell J, Tandurella J, Christenson E, Danilova L, Deshpande A, et al.
iScience
. 2025 Jan;
28(1):111569.
PMID: 39811671
Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy requires therapeutic combinations that induce quality T cells. Tumor microenvironment (TME) analysis following therapeutic interventions can identify response mechanisms, informing design of effective combinations....
5.
Bai W, Xu J, Gu W, Wang D, Cui Y, Rong W, et al.
Nat Commun
. 2025 Jan;
16(1):474.
PMID: 39774694
UHRF1 maintains DNA methylation by recruiting DNA methyltransferases to chromatin. In mouse, these dynamics are potently antagonized by a natural UHRF1 inhibitory protein STELLA, while the comparable effects of its...
6.
Baretti M, Danilova L, Durham J, Betts C, Cope L, Sidiropoulos D, et al.
Nat Commun
. 2024 Nov;
15(1):9801.
PMID: 39532835
Pancreatic ductal adenocarcinoma (PDA) is characterized by low cytotoxic lymphocytes, abundant immune-suppressive cells, and resistance to immune checkpoint inhibitors (ICI). Preclinical PDA models showed the HDAC inhibitor entinostat reduced myeloid...
7.
Graham M, Wang R, Chikarmane R, Abel B, Vaghasia A, Gupta A, et al.
Nat Commun
. 2024 Aug;
15(1):7414.
PMID: 39198404
How prostate cancer cells and their precursors mediate changes in the tumor microenvironment (TME) to drive prostate cancer progression is unclear, in part due to the inability to longitudinally study...
8.
Graham M, Xu B, Davis C, Meeker A, Heaphy C, Yegnasubramanian S, et al.
Cancer Res Commun
. 2024 Jun;
4(6):1533-1547.
PMID: 38837897
Significance: The epigenetic landscape of the TERT locus is unique in neuroblastoma. The DNA at the TERT locus, unlike other cancer cells and similar to normal cells, are hypomethylated in...
9.
Praharaj M, Shen F, Lee A, Zhao L, Nirschl T, Theodros D, et al.
Cancer Immunol Res
. 2024 May;
12(7):854-875.
PMID: 38701369
Glutamine metabolism in tumor microenvironments critically regulates antitumor immunity. Using the glutamine-antagonist prodrug JHU083, we report potent tumor growth inhibition in urologic tumors by JHU083-reprogrammed tumor-associated macrophages (TAMs) and tumor-infiltrating...
10.
Caramella-Pereira F, Zheng Q, Hicks J, Roy S, Jones T, Pomper M, et al.
medRxiv
. 2024 Apr;
PMID: 38633791
Fibroblast activation protein (FAP) is a serine protease upregulated at sites of tissue remodeling and cancer that represents a promising therapeutic and molecular imaging target. In prostate cancer, studies of...