Chad R Hancock
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Explore the profile of Chad R Hancock including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
963
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Recent Articles
31.
Fillmore N, Jacobs D, Mills D, Winder W, Hancock C
J Appl Physiol (1985)
. 2010 Jun;
109(2):511-20.
PMID: 20522731
Factors that stimulate mitochondrial biogenesis in skeletal muscle include AMP-activated protein kinase (AMPK), calcium, and circulating free fatty acids (FFAs). Chronic treatment with either 5-aminoimidazole-4-carboxamide riboside (AICAR), a chemical activator...
32.
Thomson D, Hancock C, Evanson B, Kenney S, Malan B, Mongillo A, et al.
J Appl Physiol (1985)
. 2010 Apr;
108(6):1775-85.
PMID: 20360428
Liver kinase B1 (LKB1) is a tumor-suppressing protein that is involved in the regulation of muscle metabolism and growth by phosphorylating and activating AMP-activated protein kinase (AMPK) family members. Here...
33.
Hancock C, Han D, Chen M, Terada S, Yasuda T, Wright D, et al.
Proc Natl Acad Sci U S A
. 2008 May;
105(22):7815-20.
PMID: 18509063
It has been hypothesized that insulin resistance is mediated by a deficiency of mitochondria in skeletal muscle. In keeping with this hypothesis, high-fat diets that cause insulin resistance have been...
34.
Wende A, Schaeffer P, Parker G, Zechner C, Han D, Chen M, et al.
J Biol Chem
. 2007 Oct;
282(50):36642-51.
PMID: 17932032
The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) has been identified as an inducible regulator of mitochondrial function. Skeletal muscle PGC-1alpha expression is induced post-exercise. Therefore, we sought to...
35.
Garcia-Roves P, Huss J, Han D, Hancock C, Iglesias-Gutierrez E, Chen M, et al.
Proc Natl Acad Sci U S A
. 2007 Jun;
104(25):10709-13.
PMID: 17548828
A number of studies have reported that a high-fat diet induces increases in mitochondrial fatty acid oxidation enzymes in muscle. In contrast, in two recent studies raising plasma free fatty...
36.
Hancock C, Janssen E, Terjung R
J Appl Physiol (1985)
. 2005 Oct;
100(2):406-13.
PMID: 16195390
The activity of AMP-activated protein kinase (AMPK) increases during muscle contractions as a result of elevated AMP concentration. We tested whether activation of AMPK would be altered during contractions in...
37.
Hancock C, Brault J, Wiseman R, Terjung R, Meyer R
Am J Physiol Cell Physiol
. 2005 Feb;
288(6):C1298-304.
PMID: 15689408
Metabolic control within skeletal muscle is designed to limit ADP accumulation even during conditions where ATP demand is out of balance with ATP synthesis. This is accomplished by the reactions...
38.
Hancock C, Janssen E, Terjung R
Am J Physiol Cell Physiol
. 2005 Jan;
288(6):C1287-97.
PMID: 15659712
The production of AMP by adenylate kinase (AK) and subsequent deamination by AMP deaminase limits ADP accumulation during conditions of high-energy demand in skeletal muscle. The goal of this study...