Natasha Fillmore
Overview
Explore the profile of Natasha Fillmore including associated specialties, affiliations and a list of published articles.
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29
Citations
595
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Recent Articles
1.
Kittelson K, Gasparotto Junior A, Fillmore N, da Silva Gomes R
Prog Cardiovasc Dis
. 2024 Nov;
87:26-36.
PMID: 39486671
The American Heart Association recently defined the complex interactions among the cardiovascular, renal, and metabolic systems as CKM syndrome. To promote better patient outcomes, having a more profound understanding of...
2.
Zhou R, Barnes K, Gibson S, Fillmore N
Am J Physiol Heart Circ Physiol
. 2024 Sep;
327(5):H1162-H1173.
PMID: 39269450
Regulation of energy metabolism is pivotal in the development of cardiovascular diseases. Dysregulation in mitochondrial fatty acid oxidation has been linked to cardiac lipid accumulation and diabetic cardiomyopathy. Sirtuin 1...
3.
Knoll K, Rhee Y, Fillmore N, Jurivich D, Lang J, McGrath B, et al.
Adv Geriatr Med Res
. 2024 Aug;
6(3).
PMID: 39119102
Background: The purpose of this study was to evaluate the associations of (1) individual absolute and body size normalized weakness cut-points, and (2) the collective weakness classifications on time to...
4.
Fillmore N, Hou V, Sun J, Springer D, Murphy E
PLoS One
. 2022 Mar;
17(3):e0265007.
PMID: 35259201
While fatty acid metabolism is altered under physiological conditions, alterations can also be maladaptive in diseases such as diabetes and heart failure. Peroxisome Proliferator Activated Receptor α (PPARα) is a...
5.
Sun J, Hao W, Fillmore N, Ma H, Springer D, Yu Z, et al.
J Am Heart Assoc
. 2019 Dec;
8(24):e013465.
PMID: 31818212
Background Heart failure is one of the leading causes of death in Western countries, and there is a need for new therapeutic approaches. Relaxin-2 is a peptide hormone that mediates...
6.
Fillmore N, Casin K, Sinha P, Sun J, Ma H, Boylston J, et al.
J Mol Cell Cardiol
. 2019 Sep;
136:95-101.
PMID: 31536744
TRIM72 is a membrane repair protein that protects against ischemia reperfusion (I/R) injury. We previously identified Cys (C144) on TRIM72 as a site of S-nitrosylation. To study the importance of...
7.
Wang W, Zhang L, Battiprolu P, Fukushima A, Nguyen K, Milner K, et al.
JACC Basic Transl Sci
. 2019 Jul;
4(3):385-400.
PMID: 31312761
Alterations in cardiac energy metabolism after a myocardial infarction contribute to the severity of heart failure (HF). Although fatty acid oxidation can be impaired in HF, it is unclear if...
8.
Fillmore N, Levasseur J, Fukushima A, Wagg C, Wang W, Dyck J, et al.
Mol Med
. 2018 Aug;
24(1):3.
PMID: 30134787
Background: Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a reduced...
9.
Fillmore N, Wagg C, Zhang L, Fukushima A, Lopaschuk G
Am J Physiol Endocrinol Metab
. 2018 Aug;
315(5):E1046-E1052.
PMID: 30106622
Recent studies have proposed that elevated branched-chain amino acids (BCAAs) may induce insulin resistance (IR) in muscle secondary to increased BCAA oxidation inhibiting glucose oxidation (GO) and fatty acid oxidation...
10.
Altamimi T, Thomas P, Darwesh A, Fillmore N, Mahmoud M, Zhang L, et al.
Biochem J
. 2018 Feb;
475(5):959-976.
PMID: 29438065
The role of carnitine acetyltransferase (CrAT) in regulating cardiac energy metabolism is poorly understood. CrAT modulates mitochondrial acetyl-CoA/CoA (coenzyme A) ratios, thus regulating pyruvate dehydrogenase activity and glucose oxidation. Here,...