Paul S Hafen
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Explore the profile of Paul S Hafen including associated specialties, affiliations and a list of published articles.
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18
Citations
190
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Recent Articles
1.
Hyldahl R, Gifford J, Davidson L, Hancock C, Hafen P, Parcell A, et al.
Exp Physiol
. 2024 Jan;
109(2):165-174.
PMID: 38189630
The Tour Divide (TD) is a 4385 km ultra-endurance bicycle race that follows the continental divide from Canada to Mexico. In this case study, we performed a comprehensive molecular and...
2.
Miller S, Matias C, Hafen P, Law A, Witczak C, Brault J
JCI Insight
. 2023 Nov;
9(2).
PMID: 38032735
Hyperuricemia is implicated in numerous pathologies, but the mechanisms underlying uric acid production are poorly understood. Using a combination of mouse studies, cell culture studies, and human serum samples, we...
3.
Fennel Z, Ducharme J, Berkemeier Q, Specht J, McKenna Z, Simpson S, et al.
Am J Physiol Regul Integr Comp Physiol
. 2023 Oct;
325(6):R735-R749.
PMID: 37842742
Muscle mass is balanced between hypertrophy and atrophy by cellular processes, including activation of the protein kinase B-mechanistic target of rapamycin (Akt-mTOR) signaling cascade. Stressors apart from exercise and nutrition,...
4.
Negoita F, Addinsall A, Hellberg K, Bringas C, Hafen P, Sermersheim T, et al.
Mol Metab
. 2023 Jun;
75:101761.
PMID: 37380024
Objective: The AMP-activated protein kinase (AMPK) gets activated in response to energetic stress such as contractions and plays a vital role in regulating various metabolic processes such as insulin-independent glucose...
5.
Hafen P, Law A, Matias C, Miller S, Brault J
J Appl Physiol (1985)
. 2022 Sep;
133(5):1055-1066.
PMID: 36107988
AMP deaminase 1 (AMPD1; AMP → IMP + NH) deficiency in skeletal muscle results in an inordinate accumulation of AMP during strenuous exercise, with some but not all studies reporting...
6.
Naylor B, Anderson C, Hadfield M, Parkinson D, Ahlstrom A, Hannemann A, et al.
J Proteome Res
. 2022 Sep;
21(11):2703-2714.
PMID: 36099490
The synthesis of new proteins and the degradation of old proteins in vivo can be quantified in serial samples using metabolic isotope labeling to measure turnover. Because serial biopsies in...
7.
Law A, Hafen P, Brault J
J Chromatogr B Analyt Technol Biomed Life Sci
. 2022 Jul;
1206:123351.
PMID: 35797802
ATP and its degradation products are essential metabolic and signaling molecules. Traditionally, they have been quantified via high-performance liquid chromatography (HPLC) with UV-Vis detection while utilizing phosphate buffer mobile phase,...
8.
Fennel Z, Amorim F, Deyhle M, Hafen P, Mermier C
Am J Physiol Regul Integr Comp Physiol
. 2022 May;
323(1):R133-R148.
PMID: 35536704
Skeletal muscle is an integral tissue system that plays a crucial role in the physical function of all vertebrates and is a key target for maintaining or improving health and...
9.
Hyldahl R, Hafen P, Nelson W, Ahmadi M, Pfeifer B, Mehling J, et al.
J Physiol
. 2021 Sep;
599(20):4581-4596.
PMID: 34487346
Limb disuse has profound negative consequences on both vascular and skeletal muscle health. The purpose of this investigation was to determine whether repeated application of passive heat, applied to the...
10.
Miller S, Hafen P, Law A, Springer C, Logsdon D, OConnell T, et al.
Metabolism
. 2021 Aug;
123:154864.
PMID: 34400216
Background: Skeletal muscle atrophy, whether caused by chronic disease, acute critical illness, disuse or aging, is characterized by tissue-specific decrease in oxidative capacity and broad alterations in metabolism that contribute...