Carleen Klumpp-Thomas
Overview
Explore the profile of Carleen Klumpp-Thomas including associated specialties, affiliations and a list of published articles.
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65
Citations
1180
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Recent Articles
1.
Ceribelli M, Tosto F, Zhang X, Melani C, Roschewski M, Beck E, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2413372121.
PMID: 39585996
Clinical trials in cancer are ideally built on a foundation of sound mechanistic rationale and well-validated drug activity in relevant disease models. The screening of approved and investigational drugs in...
2.
Lynch C, Margolis R, Niebler J, Travers J, Sakamuru S, Zhao T, et al.
Front Pharmacol
. 2024 Nov;
15:1448744.
PMID: 39508053
Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation,...
3.
Najera S, Ricketts C, Schmidt L, Medina J, Saito K, Ileva L, et al.
Mol Cancer Ther
. 2024 Oct;
24(2):200-213.
PMID: 39397296
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an inherited cancer syndrome caused by germline pathogenic variants in the fumarate hydratase (FH) gene. Affected individuals are at risk for developing...
4.
Yang S, Zhang L, Khan K, Travers J, Huang R, Jovanovic V, et al.
Endocrinology
. 2024 Sep;
165(10).
PMID: 39254333
There has been an alarming trend toward earlier puberty in girls, suggesting the influence of an environmental factor(s). As the reactivation of the reproductive axis during puberty is thought to...
5.
Arakawa Y, Jo U, Kumar S, Sun N, Elloumi F, Thomas A, et al.
Cancer Res Commun
. 2024 Mar;
4(3):834-848.
PMID: 38451783
Significance: ACC is a rare endocrine cancer with poor prognosis and limited therapeutic options. We report that TAK-243 is active alone and in combination with currently used therapies and with...
6.
Karkanitsa M, Li Y, Valenti S, Spathies J, Kelly S, Hunsberger S, et al.
medRxiv
. 2023 Oct;
PMID: 37904956
Due to a combination of asymptomatic or undiagnosed infections, the proportion of the United States population infected with SARS-CoV-2 was unclear from the beginning of the pandemic. We previously established...
7.
Wu J, Cheuk A, Isanogle K, Robinson C, Zhang X, Ceribelli M, et al.
Cancers (Basel)
. 2023 Aug;
15(16).
PMID: 37627061
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. Despite decades of clinical trials, the overall survival rate for patients with relapsed and metastatic disease remains below 30%, underscoring...
8.
Lynch C, Sakamuru S, Ooka M, Huang R, Klumpp-Thomas C, Shinn P, et al.
Annu Rev Pharmacol Toxicol
. 2023 Jul;
64:191-209.
PMID: 37506331
Traditionally, chemical toxicity is determined by in vivo animal studies, which are low throughput, expensive, and sometimes fail to predict compound toxicity in humans. Due to the increasing number of...
9.
Peat T, Gaikwad S, Dubois W, Gyabaah-Kessie N, Zhang S, Gorjifard S, et al.
Cancer Lett
. 2023 Jun;
568:216284.
PMID: 37356470
Drug resistance and disease progression are common in multiple myeloma (MM) patients, underscoring the need for new therapeutic combinations. A high-throughput drug screen in 47 MM cell lines and in...
10.
Cheff D, Cheng Q, Guo H, Travers J, Klumpp-Thomas C, Shen M, et al.
Redox Biol
. 2023 May;
63:102719.
PMID: 37244126
Selenoprotein glutathione peroxidases (GPX), like ubiquitously expressed GPX1 and the ferroptosis modulator GPX4, enact antioxidant activities by reducing hydroperoxides using glutathione. Overexpression of these enzymes is common in cancer and...