Sam Michael
Overview
Explore the profile of Sam Michael including associated specialties, affiliations and a list of published articles.
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Articles
58
Citations
1612
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Recent Articles
1.
Verma M, Hoxie N, Janiszewski J, Bonney C, Hall M, Michael S, et al.
SLAS Technol
. 2024 Dec;
29(6):100234.
PMID: 39638257
No abstract available.
2.
Ceribelli M, Tosto F, Zhang X, Melani C, Roschewski M, Beck E, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2413372121.
PMID: 39585996
Clinical trials in cancer are ideally built on a foundation of sound mechanistic rationale and well-validated drug activity in relevant disease models. The screening of approved and investigational drugs in...
3.
Hoxie N, Calabrese D, Itkin Z, Gomba G, Shen M, Verma M, et al.
SLAS Technol
. 2024 Oct;
29(6):100199.
PMID: 39427991
An approach is described for high-throughput quality assessment of drug candidate libraries using high-resolution acoustic ejection mass spectrometry (AEMS). Sample introduction from 1536-well plates is demonstrated for this application using...
4.
Schimetz J, Shah P, Keese C, Dehnert C, Detweiler M, Michael S, et al.
SLAS Technol
. 2023 Nov;
29(1):100116.
PMID: 37923083
Transepithelial electrical resistance (TEER) is a widely used technique for quantifying the permeability of epithelial and endothelial cell layers. However, traditional methods of measuring TEER are limited to single timepoint...
5.
Lynch C, Sakamuru S, Ooka M, Huang R, Klumpp-Thomas C, Shinn P, et al.
Annu Rev Pharmacol Toxicol
. 2023 Jul;
64:191-209.
PMID: 37506331
Traditionally, chemical toxicity is determined by in vivo animal studies, which are low throughput, expensive, and sometimes fail to predict compound toxicity in humans. Due to the increasing number of...
6.
Jovanovic V, Weber C, Slamecka J, Ryu S, Chu P, Sen C, et al.
Stem Cell Reports
. 2023 Jul;
18(8):1701-1720.
PMID: 37451260
Human gliogenesis remains poorly understood, and derivation of astrocytes from human pluripotent stem cells (hPSCs) is inefficient and cumbersome. Here, we report controlled glial differentiation from hPSCs that bypasses neurogenesis,...
7.
Nair N, Greninger P, Zhang X, Friedman A, Amzallag A, Cortez E, et al.
Nat Commun
. 2023 Jun;
14(1):3830.
PMID: 37380628
Combination of anti-cancer drugs is broadly seen as way to overcome the often-limited efficacy of single agents. The design and testing of combinations are however very challenging. Here we present...
8.
Sidky H, Young J, Girvin A, Lee E, Shao Y, Hotaling N, et al.
BMC Med Res Methodol
. 2023 Feb;
23(1):46.
PMID: 36800930
Background: Multi-institution electronic health records (EHR) are a rich source of real world data (RWD) for generating real world evidence (RWE) regarding the utilization, benefits and harms of medical interventions....
9.
Song M, Quinn R, Nguyen E, Hampton C, Sharma R, Park T, et al.
Nat Methods
. 2022 Dec;
20(1):149-161.
PMID: 36550275
Age-related macular degeneration (AMD), a leading cause of blindness, initiates in the outer-blood-retina-barrier (oBRB) formed by the retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris. The mechanisms of AMD initiation...
10.
Wang Y, Michael S, Yang S, Huang R, Cruz-Gutierrez K, Zhang Y, et al.
J Chem Inf Model
. 2022 Jun;
62(11):2659-2669.
PMID: 35653613
To deliver more therapeutics to more patients more quickly and economically is the ultimate goal of pharmaceutical researchers. The advent and rapid development of artificial intelligence (AI), in combination with...