Carla Mattos
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Explore the profile of Carla Mattos including associated specialties, affiliations and a list of published articles.
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52
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2561
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Recent Articles
1.
Hossain M, Brahme R, Miller B, Amin J, de Barros M, Schneider J, et al.
Nat Commun
. 2025 Feb;
16(1):1777.
PMID: 39971904
Covalent drug discovery efforts are growing rapidly but have major unaddressed limitations. These include high false positive rates during hit-to-lead identification; the inherent uncoupling of covalent drug concentration and effect...
2.
Johnson C, Fetics S, Davis K, Rodrigues J, Mattos C
Protein Sci
. 2023 Aug;
32(10):e4767.
PMID: 37615343
RAS GTPases are proto-oncoproteins that regulate cell growth, proliferation, and differentiation in response to extracellular signals. The signaling functions of RAS, and other small GTPases, are dependent on their ability...
3.
Volmar A, Guterres H, Zhou H, Reid D, Pavlopoulos S, Makowski L, et al.
Biophys J
. 2022 Jul;
121(19):3616-3629.
PMID: 35794829
HRas, KRas, and NRas are GTPases with a common set of effectors that control many cell-signaling pathways, including proliferation through Raf kinase. Their G-domains are nearly identical in sequence, with...
4.
Li Z, Mattos C, Buck M
Structure
. 2022 Apr;
30(6):909-916.e2.
PMID: 35381186
Dynamic allostery emphasizes a role of entropy change manifested as a sole change in protein fluctuations without structural changes. This kind of entropy-driven effect remains largely understudied. The most significant...
5.
Johnson C, Seo H, Terrell E, Yang M, KleinJan F, Gebregiworgis T, et al.
Mol Cell
. 2022 Feb;
82(5):950-968.e14.
PMID: 35202574
A unifying feature of the RAS superfamily is a conserved GTPase cycle by which these proteins transition between active and inactive states. We demonstrate that autophosphorylation of some GTPases is...
6.
Cookis T, Mattos C
Biomolecules
. 2021 Aug;
11(7).
PMID: 34356620
Ras and Raf-kinase interact through the Ras-binding (RBD) and cysteine-rich domains (CRD) of Raf to signal through the mitogen-activated protein kinase pathway, yet the molecular mechanism leading to Raf activation...
7.
Packer M, Parker J, Chung J, Li Z, Lee Y, Cookis T, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(10).
PMID: 33653954
Ras dimerization is critical for Raf activation. Here we show that the Ras binding domain of Raf (Raf-RBD) induces robust Ras dimerization at low surface densities on supported lipid bilayers...
8.
Agarwal S, Smith M, De La Rosa I, Verba K, Swartz P, Segura-Totten M, et al.
Acta Crystallogr D Struct Biol
. 2020 Oct;
76(Pt 10):1001-1014.
PMID: 33021502
The multiple-solvent crystal structure (MSCS) approach uses high concentrations of organic solvents to characterize the interactions and effects of solvents on proteins. Here, the method has been further developed and...
9.
Jang H, Banerjee A, Marcus K, Makowski L, Mattos C, Gaponenko V, et al.
Structure
. 2019 Sep;
27(11):1647-1659.e4.
PMID: 31495533
Ca-calmodulin (CaM) extracts KRas4B from the plasma membrane, suggesting that KRas4B/CaM interaction plays a role in regulating Ras signaling. To gain mechanistic insight, we provide a computational model, supported by...
10.
Marcus K, Mattos C
J Comput Chem
. 2019 Sep;
41(5):402-414.
PMID: 31483874
The Ras GTPase superfamily of proteins coordinates a diverse set of cellular outcomes, including cell morphology, vesicle transport, and cell proliferation. Primary amino acid sequence analysis has identified Specificity determinant...