Christian W Johnson
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Explore the profile of Christian W Johnson including associated specialties, affiliations and a list of published articles.
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11
Citations
300
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Recent Articles
1.
Schneider J, Kurmi K, Dai Y, Dhiman I, Joshi S, Gassaway B, et al.
Cell
. 2025 Feb;
188(5):1248-1264.e23.
PMID: 39919745
Little is known about metabolic vulnerabilities in oncogene-driven lung cancer. Here, we perform a phosphoproteomic screen in anaplastic lymphoma kinase (ALK)-rearranged ("ALK+") patient-derived cell lines and identify guanylate kinase 1...
2.
Johnson C, Haigis K
Cancer Res
. 2023 Dec;
83(24):4005-4007.
PMID: 38098448
The development of direct inhibitors of KRASG12C represents a monumental step forward in the field of oncology. Nevertheless, there is considerable opportunity to enhance response rates to KRASG12C inhibitors. In...
3.
Johnson C, Fetics S, Davis K, Rodrigues J, Mattos C
Protein Sci
. 2023 Aug;
32(10):e4767.
PMID: 37615343
RAS GTPases are proto-oncoproteins that regulate cell growth, proliferation, and differentiation in response to extracellular signals. The signaling functions of RAS, and other small GTPases, are dependent on their ability...
4.
Yang M, Tran T, Hunt B, Agnor R, Johnson C, Shui B, et al.
Cancer Res
. 2023 Aug;
83(19):3176-3183.
PMID: 37556505
Significance: An allosteric network formed by interaction between lysine 104 and residues in the switch-II domain is required for KRAS oncogenicity, which could be exploited for developing inhibitors of the...
5.
Johnson C, Seo H, Terrell E, Yang M, KleinJan F, Gebregiworgis T, et al.
Mol Cell
. 2022 Feb;
82(5):950-968.e14.
PMID: 35202574
A unifying feature of the RAS superfamily is a conserved GTPase cycle by which these proteins transition between active and inactive states. We demonstrate that autophosphorylation of some GTPases is...
6.
Johnson C, Lin Y, Reid D, Parker J, Pavlopoulos S, Dischinger P, et al.
Cell Rep
. 2019 Aug;
28(6):1538-1550.e7.
PMID: 31390567
Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of...
7.
Poulin E, Bera A, Lu J, Lin Y, Strasser S, Paulo J, et al.
Cancer Discov
. 2019 Apr;
9(6):738-755.
PMID: 30952657
is the most frequently mutated oncogene. The incidence of specific alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific...
8.
Johnson C, Reid D, Parker J, Salter S, Knihtila R, Kuzmic P, et al.
J Biol Chem
. 2017 Jun;
292(31):12981-12993.
PMID: 28630043
H-Ras, K-Ras, and N-Ras are small GTPases that are important in the control of cell proliferation, differentiation, and survival, and their mutants occur frequently in human cancers. The G-domain, which...
9.
Johnson C, Buhrman G, Ting P, Colicelli J, Mattos C
Data Brief
. 2016 Feb;
6:423-7.
PMID: 26866052
This article expands on crystal structure data for human H-RAS with mutations at position Y137, briefly described in a paper on the effects of phosphorylation of Y137 by ABL kinases...
10.
Ting P, Johnson C, Fang C, Cao X, Graeber T, Mattos C, et al.
FASEB J
. 2015 May;
29(9):3750-61.
PMID: 25999467
RAS proteins are signal transduction gatekeepers that mediate cell growth, survival, and differentiation through interactions with multiple effector proteins. The RAS effector RAS- and RAB-interacting protein 1 (RIN1) activates its...