Carla Mattos
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Explore the profile of Carla Mattos including associated specialties, affiliations and a list of published articles.
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52
Citations
2561
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Recent Articles
11.
Johnson C, Lin Y, Reid D, Parker J, Pavlopoulos S, Dischinger P, et al.
Cell Rep
. 2019 Aug;
28(6):1538-1550.e7.
PMID: 31390567
Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of...
12.
Kearney B, Schwabe M, Marcus K, Roberts D, Dechene M, Swartz P, et al.
Proteins
. 2019 Jul;
88(1):152-165.
PMID: 31294888
Water and ligand binding play critical roles in the structure and function of proteins, yet their binding sites and significance are difficult to predict a priori. Multiple solvent crystal structures...
13.
Knihtila R, Volmar A, Meilleur F, Mattos C
Acta Crystallogr F Struct Biol Commun
. 2019 Feb;
75(Pt 2):111-115.
PMID: 30713162
Neutron protein crystallography (NPC) reveals the three-dimensional structures of proteins, including the positions of H atoms. The technique is particularly suited to elucidate ambiguous catalytic steps in complex biochemical reactions....
14.
Ashkar R, Bilheux H, Bordallo H, Briber R, Callaway D, Cheng X, et al.
Acta Crystallogr D Struct Biol
. 2019 Jan;
74(Pt 12):1129-1168.
PMID: 30605130
The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded...
15.
Zhou H, Guterres H, Mattos C, Makowski L
Protein Sci
. 2018 Sep;
27(12):2023-2036.
PMID: 30230663
Wide-angle X-ray solution scattering (WAXS) patterns contain substantial information about the structure and dynamics of a protein. Solution scattering from a rigid protein can be predicted from atomic coordinate sets...
16.
Parker J, Volmar A, Pavlopoulos S, Mattos C
Structure
. 2018 May;
26(6):810-820.e4.
PMID: 29706533
Structures of wild-type K-Ras from crystals obtained in the presence of guanosine triphosphate (GTP) or its analogs have remained elusive. Of the K-Ras mutants, only K-RasG12D and K-RasQ61H are available...
17.
Parker J, Mattos C
Cold Spring Harb Perspect Med
. 2017 Oct;
8(8).
PMID: 29038336
Ras controls a multitude of cellular signaling processes, including cell proliferation, differentiation, and apoptosis. Deregulation of Ras cycling often promotes tumorigenesis and various other developmental disorders, termed RASopothies. Although the...
18.
Kauke M, Traxlmayr M, Parker J, Kiefer J, Knihtila R, McGee J, et al.
Sci Rep
. 2017 Jul;
7(1):5831.
PMID: 28724936
Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render...
19.
Johnson C, Reid D, Parker J, Salter S, Knihtila R, Kuzmic P, et al.
J Biol Chem
. 2017 Jun;
292(31):12981-12993.
PMID: 28630043
H-Ras, K-Ras, and N-Ras are small GTPases that are important in the control of cell proliferation, differentiation, and survival, and their mutants occur frequently in human cancers. The G-domain, which...
20.
Johnson C, Buhrman G, Ting P, Colicelli J, Mattos C
Data Brief
. 2016 Feb;
6:423-7.
PMID: 26866052
This article expands on crystal structure data for human H-RAS with mutations at position Y137, briefly described in a paper on the effects of phosphorylation of Y137 by ABL kinases...