Paul Swartz
Overview
Explore the profile of Paul Swartz including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
235
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0
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Recent Articles
1.
Yao L, Swartz P, Hamilton P, Clark A
Biosci Rep
. 2021 Jan;
41(1).
PMID: 33448281
Caspase (or cysteinyl-aspartate specific proteases) enzymes play important roles in apoptosis and inflammation, and the non-identical but overlapping specificity profiles (that is, cleavage recognition sequence) direct cells to different fates....
2.
Agarwal S, Smith M, De La Rosa I, Verba K, Swartz P, Segura-Totten M, et al.
Acta Crystallogr D Struct Biol
. 2020 Oct;
76(Pt 10):1001-1014.
PMID: 33021502
The multiple-solvent crystal structure (MSCS) approach uses high concentrations of organic solvents to characterize the interactions and effects of solvents on proteins. Here, the method has been further developed and...
3.
Shrestha S, Tung J, Grinshpon R, Swartz P, Hamilton P, Dimos B, et al.
J Biol Chem
. 2020 Aug;
295(43):14578-14591.
PMID: 32788218
Coral reefs are experiencing precipitous declines around the globe with coral diseases and temperature-induced bleaching being primary drivers of these declines. Regulation of apoptotic cell death is an important component...
4.
Kearney B, Schwabe M, Marcus K, Roberts D, Dechene M, Swartz P, et al.
Proteins
. 2019 Jul;
88(1):152-165.
PMID: 31294888
Water and ligand binding play critical roles in the structure and function of proteins, yet their binding sites and significance are difficult to predict a priori. Multiple solvent crystal structures...
5.
Thomas 3rd M, Grinshpon R, Swartz P, Clark A
J Biol Chem
. 2018 Feb;
293(15):5447-5461.
PMID: 29414778
Caspase-3 activation and function have been well-defined during programmed cell death, but caspase activity, at low levels, is also required for developmental processes such as lymphoid proliferation and erythroid differentiation....
6.
Carey L, Kim K, McCombs N, Swartz P, Kim C, Ghiladi R
J Biol Inorg Chem
. 2017 Nov;
23(2):209-219.
PMID: 29170897
Possessing both peroxidase and peroxygenase activities with a broad substrate profile that includes phenols, indoles, and pyrroles, the enzyme dehaloperoxidase (DHP) from Amphitrite ornata is a multifunctional catalytic hemoglobin that...
7.
Maciag J, Mackenzie S, Tucker M, Schipper J, Swartz P, Clark A
Proc Natl Acad Sci U S A
. 2016 Sep;
113(41):E6080-E6088.
PMID: 27681633
The native ensemble of caspases is described globally by a complex energy landscape where the binding of substrate selects for the active conformation, whereas targeting an allosteric site in the...
8.
Tucker M, Mackenzie S, Maciag J, Dirscherl Ackerman H, Swartz P, Yoder J, et al.
Protein Sci
. 2016 Sep;
25(11):2076-2088.
PMID: 27577093
The regulation of caspase-3 enzyme activity is a vital process in cell fate decisions leading to cell differentiation and tissue development or to apoptosis. The zebrafish, Danio rerio, has become...
9.
Cade C, Swartz P, Mackenzie S, Clark A
Biochemistry
. 2014 Oct;
53(48):7582-95.
PMID: 25343534
Caspases have several allosteric sites that bind small molecules or peptides. Allosteric regulators are known to affect caspase enzyme activity, in general, by facilitating large conformational changes that convert the...
10.
Kearney B, Johnson C, Roberts D, Swartz P, Mattos C
J Mol Biol
. 2013 Nov;
426(3):611-29.
PMID: 24189050
Ras GTPase mediates several cellular signal transduction pathways and is found mutated in a large number of cancers. It is active in the GTP-bound state, where it interacts with effector...