C J March
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Explore the profile of C J March including associated specialties, affiliations and a list of published articles.
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56
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4258
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Recent Articles
1.
Levin J, Chen J, Du M, Nelson F, Killar L, Skala S, et al.
Bioorg Med Chem Lett
. 2002 Apr;
12(8):1199-202.
PMID: 11934588
The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing novel acetylenic P1' groups was explored. In particular, compound 4t bearing a butynyloxy P1' moiety has excellent in...
2.
Levin J, Chen J, Du M, Nelson F, Wehr T, DiJoseph J, et al.
Bioorg Med Chem Lett
. 2001 Oct;
11(22):2975-8.
PMID: 11677139
Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine 4u has been identified as a...
3.
Levin J, Chen J, Du M, Hogan M, Kincaid S, Nelson F, et al.
Bioorg Med Chem Lett
. 2001 Aug;
11(16):2189-92.
PMID: 11514167
A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, MMP-13, and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and TACE were identified, including the potent, orally...
4.
Peschon J, Slack J, Reddy P, Stocking K, Sunnarborg S, Lee D, et al.
Science
. 1998 Nov;
282(5392):1281-4.
PMID: 9812885
The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-alpha converting enzyme (TACE), has been identified only in...
5.
Graddis T, Brasel K, Friend D, Srinivasan S, Wee S, Lyman S, et al.
J Biol Chem
. 1998 Jul;
273(28):17626-33.
PMID: 9651358
FLT3 ligand (FLT3L) stimulates primitive hematopoietic cells by binding to and activating the FLT3 receptor (FLT3R). We carried out a structure-activity study of human FLT3L in order to define the...
6.
Maskos K, Huber R, Bourenkov G, Bartunik H, Ellestad G, Reddy P, et al.
Proc Natl Acad Sci U S A
. 1998 May;
95(7):3408-12.
PMID: 9520379
Tumor necrosis factor-alpha (TNFalpha) is a cytokine that induces protective inflammatory reactions and kills tumor cells but also causes severe damage when produced in excess, as in rheumatoid arthritis and...
7.
Black R, Rauch C, Kozlosky C, Peschon J, Slack J, Wolfson M, et al.
Nature
. 1997 Feb;
385(6618):729-33.
PMID: 9034190
Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins. Modification of the cell surface in this way can alter the cell's responsiveness to its environment and release...
8.
Hoffman R, Moy F, Price V, Richardson J, Kaubisch D, Frieden E, et al.
J Biomol NMR
. 1996 Jun;
7(4):273-82.
PMID: 8765735
Oncostatin M (OM) is a cytokine that shares a structural and functional relationship with interleukin-6, leukemia inhibitory factor, and granulocyte-colony stimulating factor, which regulate the proliferation and differentiation of a...
9.
Smith F, Rauch C, Williams D, March C, Arthur D, Hilden J, et al.
Blood
. 1996 Feb;
87(3):1123-33.
PMID: 8562938
In our efforts to produce monoclonal antibodies that recognize cell-surface antigens expressed by hematopoietic precursor and stromal cells, we generated a monoclonal antibody, 7.1, which recognizes a 220- to 240-kD...
10.
Sudarsanam S, DuBose R, March C, Srinivasan S
Protein Sci
. 1995 Jul;
4(7):1412-20.
PMID: 7670382
We present an automated method for modeling backbones of protein loops. The method samples a database of phi i + 1 and psi i angles constructed from a nonredundant version...