The Discovery of Anthranilic Acid-based MMP Inhibitors. Part 3: Incorporation of Basic Amines

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2001 Oct 26

PMID 11677139

Citations 7

Authors

J I Levin

J M Chen

M T Du

F C Nelson

T Wehr

J F DiJoseph

L M Killar

S Skala

A Sung

M A Sharr

C E Roth

G Jin

R Cowling

L Di

M Sherman

Z B Xu

C J March

K M Mohler

R A Black

J S Skotnicki

Affiliations

Soon will be listed here.

Abstract

Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine 4u has been identified as a potent, selective, orally active inhibitor of MMP-9 and MMP-13.

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