C D Klaassen
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Explore the profile of C D Klaassen including associated specialties, affiliations and a list of published articles.
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391
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4169
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Recent Articles
11.
Slitt A, Cherrington N, Maher J, Klaassen C
Drug Metab Dispos
. 2003 Aug;
31(9):1176-86.
PMID: 12920174
Treatment with the microsomal enzyme inducer trans-stilbene oxide (TSO) can decrease biliary excretion of acetaminophen-glucuronide (AA-GLUC) and increase efflux of AA-GLUC into blood. The hepatic canalicular multidrug resistance protein (Mrp)...
12.
Shelby M, Cherrington N, Vansell N, Klaassen C
Drug Metab Dispos
. 2003 Feb;
31(3):326-33.
PMID: 12584160
UDP-Glucuronosyltransferases (UGTs) are phase II biotransformation enzymes that glucuronidate numerous endobiotic and xenobiotic substrates. Glucuronidation increases the water solubility of the substrate and facilitates renal and biliary excretion of the...
13.
Slitt A, Cherrington N, Hartley D, Leazer T, Klaassen C
Drug Metab Dispos
. 2002 Jan;
30(2):212-9.
PMID: 11792693
Organic cation transporters (OCTs) are responsible for excretion of cationic substances into urine. Tissue OCT expression may be important for the disposition and excretion of xenobiotics. Therefore, OCT1, OCT2, OCT3,...
14.
Habeebu S, Liu Y, Park J, Klaassen C
Toxicol Appl Pharmacol
. 2001 Dec;
177(3):200-7.
PMID: 11749119
Cadmium (Cd) is toxic to sensory ganglia in many animal species. Cadmium uptake is low in the central nervous system, but it distributes preferentially to peripheral sensory and autonomic ganglia....
15.
Vansell N, Klaassen C
Toxicol Appl Pharmacol
. 2001 Nov;
176(3):187-94.
PMID: 11714251
The extrathyroidal mechanism by which endocrine disruptors promote thyroid tumors has been proposed to be increased glucuronidation and biliary elimination of thyroxine (T(4)), followed by disruption of the hypothalamic-pituitary-thyroid axis....
16.
Guo G, Klaassen C
J Pharmacol Exp Ther
. 2001 Oct;
299(2):551-7.
PMID: 11602666
Rat oatp1 (Slc21a1) and oatp2 (Slc21a5) transport many structurally unrelated endogenous and exogenous compounds across the sinusoidal membrane of hepatocytes in a sodium-independent manner. There are several potential protein kinase...
17.
Staudinger J, Liu Y, Madan A, Habeebu S, Klaassen C
Drug Metab Dispos
. 2001 Oct;
29(11):1467-72.
PMID: 11602523
Identification and characterization of the pregnane X receptor (PXR) as a key regulator of cytochrome P450 3A (CYP3A) gene expression has led to an increased understanding of the molecular basis...
18.
Liu J, Corton C, Dix D, Liu Y, Waalkes M, Klaassen C
Toxicol Appl Pharmacol
. 2001 Oct;
176(1):1-9.
PMID: 11578143
Sensitivity to cadmium (Cd)-induced testicular injury varies greatly among mouse strains. For instance, 129/SvJ (129) mice are highly sensitive while C57BL/6J (C57) mice are refractory to Cd-induced testicular injury. Metallothionein...
19.
Liu Y, Liu J, Klaassen C
Toxicol Appl Pharmacol
. 2001 Sep;
175(3):253-9.
PMID: 11559024
Cadmium (Cd) is an environmental pollutant and is toxic to many tissues. Food is the primary source of Cd exposure for the general population. Metallothionein (MT), a cysteine-rich, Cd-binding protein,...
20.
Takiguchi M, Cherrington N, Hartley D, Klaassen C, Waalkes M
Toxicology
. 2001 Sep;
165(1):13-25.
PMID: 11551428
Several reports indicate that some steroids, in particular sex steroid hormones, can modify cadmium toxicity. We recently reported that cyproterone acetate (CA), a synthetic steroidal antiandrogen that is closely related...