J M McKim Jr
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Explore the profile of J M McKim Jr including associated specialties, affiliations and a list of published articles.
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24
Citations
230
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Recent Articles
1.
Casas J, Lewerenz G, Rankin E, Willoughby Sr J, Blakeman L, McKim Jr J, et al.
Toxicol In Vitro
. 2013 Sep;
27(8):2175-83.
PMID: 23999410
The aim of this study was to determine if the EpiDerm™ reconstructed human skin model (MatTek Corp.) could be an acceptable alternative to the ISO 10993-required rabbit skin irritation test...
2.
McKim Jr J, Wilga P, Breslin W, Plotzke K, Gallavan R, Meeks R
Toxicol Sci
. 2001 Aug;
63(1):37-46.
PMID: 11509742
The cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) have numerous industrial and consumer applications and thus have the potential for human exposure. The present study was undertaken...
3.
McKim Jr J, Kolesar G, Jean P, Meeker L, Wilga P, Schoonhoven R, et al.
Toxicol Appl Pharmacol
. 2001 Apr;
172(2):83-92.
PMID: 11298494
Octamethylcyclotetrasiloxane (D4) has been described as a phenobarbital-like inducer of hepatic enzymes. Phenobarbital (PB) and phenobarbital-like chemicals induce transient hepatic and thyroid hyperplasia and sustained hypertrophy in rats and mice....
4.
McKim Jr J, Choudhuri S, Wilga P, Madan A, Burns-Naas L, Gallavan R, et al.
Toxicol Sci
. 1999 Aug;
50(1):10-9.
PMID: 10445748
Decamethylcyclopentasiloxane (D5) is a cyclic siloxane with a wide range of commercial applications. The present study was designed to investigate the effects of D5 on the expression and activity of...
5.
McKim Jr J, Wilga P, Kolesar G, Choudhuri S, Madan A, Dochterman L, et al.
Toxicol Sci
. 1998 Apr;
41(1):29-41.
PMID: 9520339
Repeated inhalation exposure to octamethylcyclotetrasiloxane (D4) produces a reversible and dose-related hepatomegaly and proliferation of hepatic endoplasmic reticulum in rats. However, the effects of D4 on the expression of cytochrome...
6.
Sokol R, McKim Jr J, Goff M, Ruyle S, Devereaux M, Han D, et al.
Gastroenterology
. 1998 Jan;
114(1):164-74.
PMID: 9428230
Background & Aims: Hydrophobic bile acids have been implicated in the pathogenesis of cholestatic liver injury. The hypothesis that hydrophobic bile acid toxicity is mediated by oxidant stress in an...
7.
Sokol R, McKim Jr J, Devereaux M
Pediatr Res
. 1996 Feb;
39(2):259-63.
PMID: 8825797
The objective of this study was to determine the role of oxidant stress in cell injury produced by in vivo copper overload of isolated rat hepatocytes. Rats were maintained on...
8.
Sokol R, Winklhofer-Roob B, Devereaux M, McKim Jr J
Gastroenterology
. 1995 Oct;
109(4):1249-56.
PMID: 7557092
Background & Aims: The mechanisms causing liver injury in cholestatic diseases are unclear. The hypothesis that accumulation of hydrophobic bile acids in hepatocytes during cholestasis leads to generation of oxygen...
9.
Sokol R, Twedt D, McKim Jr J, Devereaux M, Karrer F, Kam I, et al.
Gastroenterology
. 1994 Dec;
107(6):1788-98.
PMID: 7958693
Background/aims: Copper overload leads to liver injury in humans with Wilson's disease and in Bedlington terriers with copper toxicosis; however, the mechanisms of liver injury are poorly understood. This study...
10.
Klaassen C, Choudhuri S, McKim Jr J, Kershaw W
Environ Health Perspect
. 1994 Sep;
102 Suppl 3:141-6.
PMID: 7843089
Degradation of metallothionein (MT) from rat liver was examined. Degradation of apo-MT by liver homogenate was greater than that by cytosol. At pH 5.5, degradation by homogenate was more than...