Bryce A Nordhues
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Explore the profile of Bryce A Nordhues including associated specialties, affiliations and a list of published articles.
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20
Citations
1109
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Recent Articles
11.
Fontaine S, Rauch J, Nordhues B, Assimon V, Stothert A, Jinwal U, et al.
J Biol Chem
. 2015 Apr;
290(21):13115-27.
PMID: 25864199
The constitutively expressed heat shock protein 70 kDa (Hsc70) is a major chaperone protein responsible for maintaining proteostasis, yet how its structure translates into functional decisions regarding client fate is...
12.
Blair L, Frauen H, Zhang B, Nordhues B, Bijan S, Lin Y, et al.
Acta Neuropathol Commun
. 2015 Mar;
3:8.
PMID: 25775028
Introduction: The blood-brain barrier (BBB) is damaged in tauopathies, including progressive supranuclear palsy (PSP) and Alzheimer's disease (AD), which is thought to contribute to pathogenesis later in the disease course....
13.
Sabbagh J, OLeary 3rd J, Blair L, Klengel T, Nordhues B, Fontaine S, et al.
PLoS One
. 2014 Sep;
9(9):e107241.
PMID: 25191701
Single nucleotide polymorphisms (SNPs) in the FK506 binding protein 5 (FKBP5) gene combine with traumatic events to increase risk for post-traumatic stress and major depressive disorders (PTSD and MDD). These...
14.
Selenica M, Davtyan H, Housley S, Blair L, Gillies A, Nordhues B, et al.
J Neuroinflammation
. 2014 Sep;
11:152.
PMID: 25183004
Background: Abnormal tau hyperphosphorylation and its accumulation into intra-neuronal neurofibrillary tangles are linked to neurodegeneration in Alzheimer's disease and similar tauopathies. One strategy to reduce accumulation is through immunization, but...
15.
Karagoz G, Duarte A, Akoury E, Ippel H, Biernat J, Luengo T, et al.
Cell
. 2014 Mar;
156(5):963-74.
PMID: 24581495
Protein folding in the cell relies on the orchestrated action of conserved families of molecular chaperones, the Hsp70 and Hsp90 systems. Hsp70 acts early and Hsp90 late in the folding...
16.
Blair L, Nordhues B, Hill S, Scaglione K, OLeary 3rd J, Fontaine S, et al.
J Clin Invest
. 2013 Sep;
123(10):4158-69.
PMID: 23999428
Aggregation of tau protein in the brain is associated with a class of neurodegenerative diseases known as tauopathies. FK506 binding protein 51 kDa (FKBP51, encoded by FKBP5) forms a mature...
17.
Abisambra J, Jinwal U, Blair L, OLeary 3rd J, Li Q, Brady S, et al.
J Neurosci
. 2013 May;
33(22):9498-507.
PMID: 23719816
In Alzheimer's disease (AD), the mechanisms of neuronal loss remain largely unknown. Although tau pathology is closely correlated with neuronal loss, how its accumulation may lead to activation of neurotoxic...
18.
Jinwal U, Akoury E, Abisambra J, OLeary 3rd J, Thompson A, Blair L, et al.
FASEB J
. 2012 Dec;
27(4):1450-9.
PMID: 23271055
Dysfunctional tau accumulation is a major contributing factor in tauopathies, and the heat-shock protein 70 (Hsp70) seems to play an important role in this accumulation. Several reports suggest that Hsp70...
19.
Chatterjee S, Zhong D, Nordhues B, Battaile K, Lovell S, De Guzman R
Protein Sci
. 2010 Oct;
20(1):75-86.
PMID: 21031487
The type III secretion system (T3SS) is a protein injection nanomachinery required for virulence by many human pathogenic bacteria including Salmonella and Shigella. An essential component of the T3SS is...
20.
Wang Y, Nordhues B, Zhong D, De Guzman R
Biochemistry
. 2010 Apr;
49(19):4220-6.
PMID: 20397637
Salmonella and Shigella bacteria require the type III secretion system (T3SS) to inject virulence proteins into their hosts and initiate infections. The tip proteins SipD and IpaD are critical components...