Bryce A Nordhues
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Explore the profile of Bryce A Nordhues including associated specialties, affiliations and a list of published articles.
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20
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1109
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Recent Articles
1.
Blair L, Criado-Marrero M, Zheng D, Wang X, Kamath S, Nordhues B, et al.
eNeuro
. 2019 Apr;
6(1).
PMID: 30963102
Increased expression of the FK506-binding protein 5 () gene has been associated with a number of diseases, but most prominently in connection to psychiatric illnesses. Many of these psychiatric disorders...
2.
Sabbagh J, Cordova R, Zheng D, Criado-Marrero M, Lemus A, Li P, et al.
ACS Chem Biol
. 2018 Jun;
13(8):2288-2299.
PMID: 29893552
Genetic and epigenetic alterations in FK506-binding protein 5 ( FKBP5) have been associated with increased risk for psychiatric disorders, including post-traumatic stress disorder (PTSD). Some of these common variants can...
3.
Taylor I, Ahmad A, Wu T, Nordhues B, Bhullar A, Gestwicki J, et al.
J Biol Chem
. 2018 May;
293(27):10796-10809.
PMID: 29764935
Hsp70 chaperones bind to various protein substrates for folding, trafficking, and degradation. Considerable structural information is available about how prokaryotic Hsp70 (DnaK) binds substrates, but less is known about mammalian...
4.
Stothert A, Suntharalingam A, Tang X, Crowley V, Mishra S, Webster J, et al.
Sci Rep
. 2017 Dec;
7(1):17951.
PMID: 29263415
The heat shock protein 90 (Hsp90) family of molecular chaperones regulates protein homeostasis, folding, and degradation. The ER-resident Hsp90 isoform, glucose-regulated protein 94 (Grp94), promotes the aggregation of mutant forms...
5.
Shelton L, Baker J, Zheng D, Sullivan L, Solanki P, Webster J, et al.
Proc Natl Acad Sci U S A
. 2017 Aug;
114(36):9707-9712.
PMID: 28827321
The microtubule-associated protein tau (MAPT, tau) forms neurotoxic aggregates that promote cognitive deficits in tauopathies, the most common of which is Alzheimer's disease (AD). The 90-kDa heat shock protein (Hsp90)...
6.
Baker J, Shelton L, Zheng D, Favretto F, Nordhues B, Darling A, et al.
PLoS Biol
. 2017 Jun;
15(6):e2001336.
PMID: 28654636
The accumulation of amyloidogenic proteins is a pathological hallmark of neurodegenerative disorders. The aberrant accumulation of the microtubule associating protein tau (MAPT, tau) into toxic oligomers and amyloid deposits is...
7.
Fontaine S, Zheng D, Sabbagh J, Martin M, Chaput D, Darling A, et al.
EMBO J
. 2016 Jun;
35(14):1537-49.
PMID: 27261198
It is now known that proteins associated with neurodegenerative disease can spread throughout the brain in a prionlike manner. However, the mechanisms regulating the trans-synaptic spread propagation, including the neuronal...
8.
Martin M, Baker J, Suntharalingam A, Nordhues B, Shelton L, Zheng D, et al.
ACS Chem Biol
. 2016 May;
11(7):2041-8.
PMID: 27177119
Three scaffolds with inhibitory activity against the heat shock protein 70 (Hsp70) family of chaperones have been found to enhance the degradation of the microtubule associated protein tau in cells,...
9.
Chaudhury S, Nordhues B, Kaur K, Zhang N, De Guzman R
Biochemistry
. 2015 Oct;
54(43):6576-85.
PMID: 26451841
Lung infection with Pseudomonas aeruginosa is the leading cause of death among cystic fibrosis patients. To initiate infection, P. aeruginosa assembles a protein nanomachine, the type III secretion system (T3SS),...
10.
Fontaine S, Martin M, Akoury E, Assimon V, Borysov S, Nordhues B, et al.
Hum Mol Genet
. 2015 Apr;
24(14):3971-81.
PMID: 25882706
The pathological accumulation of abnormally hyperphosphorylated and aggregated tau, a neuronal microtubule (MT)-associated protein that functions to maintain MT stability, is implicated in a number of hereditary and sporadic neurodegenerative...