Brian H Shilton
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Explore the profile of Brian H Shilton including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
964
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Recent Articles
1.
Islam F, Leung K, Walker M, Al Massri S, Shilton B
Front Pharmacol
. 2022 May;
13:838500.
PMID: 35517822
Human Quinone Reductase 2 (NQO2) is a pharmacological target and has appeared in numerous screening efforts as an off-target interactor with kinase-targeted drugs. However the cellular functions of NQO2 are...
2.
Tejada M, Sudhakar S, Kim N, Aoyama H, Shilton B, Bai D
Biochem J
. 2018 Oct;
475(21):3315-3330.
PMID: 30287491
Gap junction (GJ) channels are oligomers of connexins forming channels linking neighboring cells. GJs formed by different connexins show distinct unitary channel conductance (γ), transjunctional voltage-dependent gating (-gating) properties, and...
3.
Luscher B, Butepage M, Eckei L, Krieg S, Verheugd P, Shilton B
Chem Rev
. 2017 Nov;
118(3):1092-1136.
PMID: 29172462
Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine dinucleotide (NAD) to modify target proteins with ADP-ribose. This modification can occur...
4.
Yazdi A, Vezina G, Shilton B
Sci Rep
. 2017 Sep;
7(1):11747.
PMID: 28924213
SecA is the ATPase of preprotein translocase. SecA is a dimer in solution and changes in its oligomeric state may function in preprotein translocation. The SecA-N68 construct, in which the...
5.
Yazdi A, Namjoshi S, Hackett J, Ghonaim N, Shilton B
FEBS Lett
. 2017 Sep;
591(20):3378-3390.
PMID: 28862749
We coupled peptides from a CNBr digest of signal-sequenceless maltose-binding protein (MBP) to a surface plasmon resonance chip. SecA-N95, SecA-N68, and SecA-DM (which consists of only the DEAD Motor domains...
6.
Hoffman K, Berg M, Shilton B, Brandl C, ODonoghue P
Nucleic Acids Res
. 2016 Dec;
45(6):3407-3421.
PMID: 27899648
Despite the general requirement for translation fidelity, mistranslation can be an adaptive response. We selected spontaneous second site mutations that suppress the stress sensitivity caused by a Saccharomyces cerevisiae tti2...
7.
Morey T, Albers S, Shilton B, Rylett R
J Neurochem
. 2016 Feb;
137(4):630-46.
PMID: 26871972
Choline acetyltransferase (ChAT) is essential for cholinergic neuron function as it mediates synthesis of the neurotransmitter acetylcholine. ChAT mutations have been linked to the neuromuscular disorder congenital myasthenic syndrome (CMS)....
8.
Leung K, Shilton B
Biochemistry
. 2015 Dec;
54(51):7438-48.
PMID: 26636353
Quinone reductase 2 (NQO2) is an enzyme that might have intracellular signaling functions. NQO2 can exist in either an oxidized state or a reduced state, and binding of compounds to...
9.
Tong X, Aoyama H, Sudhakar S, Chen H, Shilton B, Bai D
PLoS One
. 2015 Dec;
10(12):e0143876.
PMID: 26625162
Gap junction (GJ) channels provide direct passage for ions and small molecules to be exchanged between neighbouring cells and are crucial for many physiological processes. GJ channels can be gated...
10.
Killoran R, Fan J, Yang D, Shilton B, Choy W
PLoS One
. 2015 Apr;
10(4):e0123934.
PMID: 25909186
The partially disordered Chibby (Cby) is a conserved nuclear protein that antagonizes the Wnt/β-catenin signaling pathway. By competing with the Tcf/Lef family proteins for binding to β-catenin, Cby abrogates the...