Brian R Dempsey
Overview
Explore the profile of Brian R Dempsey including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
65
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Recent Articles
1.
Chen L, Dempsey B, Gyenis L, Menassa R, Brandle J, Dhaubhadel S
Plant Biotechnol J
. 2013 Jan;
11(5):546-54.
PMID: 23301867
Plants are one of the most economical platforms for large-scale production of recombinant proteins for biopharmaceutical and industrial uses. A large number of human recombinant proteins of therapeutic value have...
2.
Dempsey B, Rezvanpour A, Lee T, Barber K, Junop M, Shaw G
Structure
. 2012 Sep;
20(10):1737-45.
PMID: 22940583
Plasma membrane repair involves the coordinated effort of proteins and the inner phospholipid surface to mend the rupture and return the cell back to homeostasis. Here, we present the three-dimensional...
3.
Dempsey B, Shaw G
Biochemistry
. 2011 Sep;
50(42):9056-65.
PMID: 21932834
S100B is a dimeric EF-hand protein that undergoes a calcium-induced conformational change and exposes a hydrophobic protein-binding surface. Recently S100B was identified as a binding partner of the dopamine D2...
4.
Duncan K, Dempsey B, Killip L, Adams J, Bailey M, Lajoie G, et al.
J Med Chem
. 2011 May;
54(11):3854-65.
PMID: 21545152
Phage panning led to the discovery of a disulfide-cyclized peptide CRYPEVEIC that inhibits Pin1 activity with a K(I) of 0.5 μM. NMR chemical shift perturbation experiments show that cyclic CRYPEVEIC...
5.
Dempsey B, Wrona M, Moulin J, Gloor G, Jalilehvand F, Lajoie G, et al.
Biochemistry
. 2004 Jul;
43(29):9361-71.
PMID: 15260479
The solution NMR structure of a 22-residue Zn(2+)-binding domain (ZBD) from Esherichia coli preprotein translocase subunit SecA is presented. In conjunction with X-ray absorption analysis, the NMR structure shows that...
6.
Dempsey B, Economou A, Dunn S, Shilton B
J Mol Biol
. 2002 Jan;
315(4):831-43.
PMID: 11812151
Preprotein translocase is a general and essential system for bacterial protein export, the minimal components of which are SecA and SecYEG. SecA is a peripheral ATPase that associates with nucleotide,...