Brian H Shilton
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Explore the profile of Brian H Shilton including associated specialties, affiliations and a list of published articles.
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45
Citations
964
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Recent Articles
11.
Shilton B
Biochem J
. 2015 Apr;
467(2):193-9.
PMID: 25837849
Active membrane transporters are dynamic molecular machines that catalyse transport across a membrane by coupling solute movement to a source of energy such as ATP or a secondary ion gradient....
12.
Cook B, Barber K, Shilton B, Shaw G
PLoS One
. 2015 Mar;
10(3):e0120318.
PMID: 25799589
Polyubiquitination is a post-translational event used to control the degradation of damaged or unwanted proteins by modifying the target protein with a chain of ubiquitin molecules. One potential mechanism for...
13.
Litchfield D, Shilton B, Brandl C, Gyenis L
Biochim Biophys Acta
. 2015 Mar;
1850(10):2077-86.
PMID: 25766872
Background: Protein phosphorylation is a universal regulatory mechanism that involves an extensive network of protein kinases. The discovery of the phosphorylation-dependent peptidyl-prolyl isomerase Pin1 added an additional layer of complexity...
14.
Innes B, Sowole M, Gyenis L, Dubinsky M, Konermann L, Litchfield D, et al.
Biochim Biophys Acta
. 2015 Jan;
1852(5):905-12.
PMID: 25595659
Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase that plays a critical role in mediating protein conformational changes involved in signaling processes related to cell cycle control. Pin1 has also been implicated...
15.
Leung K, Shilton B
Biochemistry
. 2014 Nov;
54(1):47-59.
PMID: 25379648
Quinone reductase 2 (NQO2) exhibits off-target interactions with two protein kinase CK2 inhibitors, 4,5,6,7-1H-tetrabromobenzimidazole (TBBz) and 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole (DMAT). TBBz and DMAT induce apoptosis in cells expressing an inhibitor-resistant CK2, suggesting...
16.
Podkowa K, Briere L, Heinrichs D, Shilton B
Biochemistry
. 2014 Mar;
53(12):2017-31.
PMID: 24606332
Iron acquisition is a central process for virtually all organisms. In Staphylococcus aureus, FhuD2 is a lipoprotein that is a high-affinity receptor for iron-bound hydroxamate siderophores. In this study, FhuD2...
17.
Lam S, Ma X, Sing T, Shilton B, Brandl C, Davey M
PLoS One
. 2013 Dec;
8(12):e82177.
PMID: 24349215
The pre-sensor 1 (PS1) hairpin is found in ring-shaped helicases of the AAA+ family (ATPases associated with a variety of cellular activities) of proteins and is implicated in DNA translocation...
18.
Leung K, Shilton B
J Biol Chem
. 2013 Mar;
288(16):11242-51.
PMID: 23471972
Quinone reductase 2 (NQO2) is an FAD-linked enzyme and the only known human target of two antimalarial drugs, primaquine (PQ) and chloroquine (CQ). The structural differences between oxidized and reduced...
19.
Innes B, Bailey M, Brandl C, Shilton B, Litchfield D
Front Physiol
. 2013 Feb;
4:18.
PMID: 23407864
Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase (PPIase) that has the potential to add an additional level of regulation within protein kinase mediated signaling pathways. Furthermore, there is a mounting body...
20.
Whitfield C, Shilton B, Haniford D
Mob DNA
. 2012 Apr;
3:7.
PMID: 22503096
Background: The H-NS protein is a global regulator of gene expression in bacteria and can also bind transposition complexes (transpososomes). In Tn5 transposition H-NS promotes transpososome assembly in vitro and...