Brian B Haab
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Explore the profile of Brian B Haab including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Haab B, Klamer Z
Mol Cell Proteomics
. 2019 Dec;
19(2):224-232.
PMID: 31848260
Proteins that bind carbohydrate structures can serve as tools to quantify or localize specific glycans in biological specimens. Such proteins, including lectins and glycan-binding antibodies, are particularly valuable if accurate...
12.
Black A, Liang H, West C, Wang M, Herrera H, Haab B, et al.
Anal Chem
. 2019 Jun;
91(13):8429-8435.
PMID: 31177770
A new platform for N-glycoprotein analysis from serum that combines matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) workflows with antibody slide arrays is described. Antibody panel based (APB) N-glycan...
13.
Staal B, Liu Y, Barnett D, Hsueh P, He Z, Gao C, et al.
Clin Cancer Res
. 2019 Jan;
25(9):2745-2754.
PMID: 30617132
Purpose: The CA19-9 biomarker is elevated in a substantial group of patients with pancreatic ductal adenocarcinoma (PDAC), but not enough to be reliable for the detection or diagnosis of the...
14.
Barnett D, Liu Y, Partyka K, Huang Y, Tang H, Hostetter G, et al.
Sci Rep
. 2017 Jun;
7(1):4020.
PMID: 28642461
Molecular markers to detect subtypes of cancer cells could facilitate more effective treatment. We recently identified a carbohydrate antigen, named sTRA, that is as accurate a serological biomarker of pancreatic...
15.
Sinha J, Cao Z, Dai J, Tang H, Partyka K, Hostetter G, et al.
PLoS One
. 2016 Dec;
11(12):e0167070.
PMID: 27992432
Molecular indicators to specify the risk posed by a pancreatic cyst would benefit patients. Previously we showed that most cancer-precursor cysts, termed mucinous cysts, produce abnormal glycoforms of the proteins...
16.
Reatini B, Ensink E, Liau B, Sinha J, Powers T, Partyka K, et al.
Anal Chem
. 2016 Nov;
88(23):11584-11592.
PMID: 27809484
Glycans are critical to protein biology and are useful as disease biomarkers. Many studies of glycans rely on clinical specimens, but the low amount of sample available for some specimens...
17.
Tang H, Partyka K, Hsueh P, Sinha J, Kletter D, Zeh H, et al.
Cell Mol Gastroenterol Hepatol
. 2016 Mar;
2(2):201-221.e15.
PMID: 26998508
Background And Aims: The CA19-9 antigen is the current best biomarker for pancreatic cancer, but it is not elevated in about 25% of pancreatic cancer patients at a cutoff that...
18.
Sajda T, Hazelton J, Patel M, Seiffert-Sinha K, Steinman L, Robinson W, et al.
Proc Natl Acad Sci U S A
. 2016 Feb;
113(7):1859-64.
PMID: 26831096
Patients with pemphigus vulgaris (PV) harbor antibodies reactive against self-antigens expressed at the surface of keratinocytes, primarily desmoglein (Dsg) 3 and, to a lesser extent, Dsg1. Conventionally, only antibodies targeting...
19.
Haab B, Huang Y, Balasenthil S, Partyka K, Tang H, Anderson M, et al.
PLoS One
. 2015 Oct;
10(10):e0139049.
PMID: 26431551
The validation of candidate biomarkers often is hampered by the lack of a reliable means of assessing and comparing performance. We present here a reference set of serum and plasma...
20.
Ensink E, Sinha J, Sinha A, Tang H, Calderone H, Hostetter G, et al.
Anal Chem
. 2015 Sep;
87(19):9715-21.
PMID: 26339978
Experiments involving the high-throughput quantification of image data require algorithms for automation. A challenge in the development of such algorithms is to properly interpret signals over a broad range of...