Marshall Bern
Overview
Explore the profile of Marshall Bern including associated specialties, affiliations and a list of published articles.
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71
Citations
1719
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Recent Articles
1.
Waldenmaier H, Gorre E, Poltash M, Gunawardena H, Zhai X, Li J, et al.
J Am Soc Mass Spectrom
. 2023 May;
34(6):1073-1085.
PMID: 37186948
Here we describe a state-of-the-art, integrated, multi-instrument automated system designed to execute methods involved in mass spectrometry characterization of biotherapeutics. The system includes liquid and microplate handling robotics and utilities,...
2.
Wecksler A, Veale L, Basanta-Sanchez M, Bern M
J Am Soc Mass Spectrom
. 2022 Feb;
33(3):598-602.
PMID: 35157447
Detection and characterization of cross-linked peptides of unknown chemical nature and location is challenging. An analytical workflow based on the use of O-labeling tryptic digestion ( 2013, 85, 5900-5908) was...
3.
Santos I, Lanzillotti M, Shilov I, Basanta-Sanchez M, Roushan A, Lawler R, et al.
J Am Soc Mass Spectrom
. 2022 Feb;
33(3):510-520.
PMID: 35157441
With the increased development of new RNA-based therapeutics, the need for robust analytical methods for confirming sequences and mapping modifications has accelerated. Characterizing modified ribonucleic acids using mass spectrometry is...
4.
Kawahara R, Chernykh A, Alagesan K, Bern M, Cao W, Chalkley R, et al.
Nat Methods
. 2021 Dec;
19(1):130.
PMID: 34893784
No abstract available.
5.
Kawahara R, Chernykh A, Alagesan K, Bern M, Cao W, Chalkley R, et al.
Nat Methods
. 2021 Nov;
18(11):1304-1316.
PMID: 34725484
Glycoproteomics is a powerful yet analytically challenging research tool. Software packages aiding the interpretation of complex glycopeptide tandem mass spectra have appeared, but their relative performance remains untested. Conducted through...
6.
Patel A, Turner R, Rifflet A, Acosta-Martin A, Nichols A, Awad M, et al.
Elife
. 2021 Sep;
10.
PMID: 34579805
Many software solutions are available for proteomics and glycomics studies, but none are ideal for the structural analysis of peptidoglycan (PG), the essential and major component of bacterial cell envelopes....
7.
Nichols A, Kil Y, Mahan A, Zhai B, Hepler R, Nields K, et al.
J Am Soc Mass Spectrom
. 2021 Mar;
32(8):2013-2018.
PMID: 33765378
In the never-ending endeavor to produce stable and efficacious protein therapeutics, biopharmaceutical companies often employ numerous analytical techniques to characterize and quantify a drug candidate's stability. Mass spectrometry, due to...
8.
Caval T, Hecht E, Tang W, Uy-Gomez M, Nichols A, Kil Y, et al.
FEBS J
. 2021 Mar;
288(18):5389-5405.
PMID: 33713388
Mass spectrometry is gaining momentum as a method of choice to de novo sequence antibodies (Abs). Adequate sequence coverage of the hypervariable regions remains one of the toughest identification challenges...
9.
Roushan A, Wilson G, Kletter D, Sen K, Tang W, Kil Y, et al.
Mol Cell Proteomics
. 2021 Feb;
20:100011.
PMID: 33578083
Glycopeptides in peptide or digested protein samples pose a number of analytical and bioinformatics challenges beyond those posed by unmodified peptides or peptides with smaller posttranslational modifications. Exact structural elucidation...
10.
Sandoz K, Moore R, Beare P, Patel A, Smith R, Bern M, et al.
Nat Microbiol
. 2020 Nov;
6(1):19-26.
PMID: 33139883
Gram-negative bacteria have a cell envelope that comprises an outer membrane (OM), a peptidoglycan (PG) layer and an inner membrane (IM). The OM and PG are load-bearing, selectively permeable structures...